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Gentisin

Catalog No. TN1683 CAS 437-50-3

Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 μM. Gentisin has mutagenic activity.

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Gentisin, CAS 437-50-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 422.00
5 mg	In stock	$ 981.00
10 mg	In stock	$ 1,350.00
25 mg	In stock	$ 1,960.00
50 mg	In stock	$ 2,680.00
1 mL * 10 mM (in DMSO)	In stock	$ 1,080.00

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Purity: 95.34%

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Description	Gentisin is a novel inhibitor of vascular smooth muscle cells (VSMC) proliferation with an IC50 value of 7.84 μM. Gentisin has mutagenic activity.
Targets&IC50	VSMC cells:7.84 μM
In vitro	The anti-proliferative effect of Gentisin was confirmed by the quantification of DNA synthesis (BrdU incorporation) in VSMC. Cell death quantification (determined by LDH release in the culture medium) revealed that Gentisin was not cytotoxic in the investigated concentration range[1].
Source	Natural Products > Gentianaceae > Gentiana

Molecular Weight	258.23
Formula	C14H10O5
CAS No.	437-50-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 80 mg/mL (309.80 mM)

References and Literature

1. Waltenberger B, et al. Nonprenylated Xanthones from Gentiana lutea, Frasera caroliniensis, and Centaurium erythraea as Novel Inhibitors of Vascular Smooth Muscle Cell Proliferation. Molecules. 2015 Nov 13;20(11):20381-90.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Traditional Chinese Medicine Monomer Library DNA Damage & Repair Compound Library RO5 Drug-like Natural Product Library Selected Plant-Sourced Compound Library Human Endogenous Metabolite Compound Library Plus Natural Product Library for HTS Anti-Gastroenteritis Natural Product Library Bioactive Compound Library Human Metabolite Library

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Keywords

Gentisin 437-50-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis inhibit Inhibitor inhibitor

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