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Ginsenoside Rs3

Catalog No. TN1688 CAS 194861-70-6

Synonyms: 人参皂苷RS3

Ginsenoside Rs3 induce apoptosis, is related to the elevations of p53 and p21WAF1 in the cells.

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Ginsenoside Rs3, CAS 194861-70-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Ginsenoside Rs3 induce apoptosis, is related to the elevations of p53 and p21WAF1 in the cells.

In vitro

Ginsenoside Rs3 (G-Rs3), a new diol-type ginseng saponin isolated from the roots of Panax ginseng C.A. Meyer, efficiently arrests the cell cycle at the G1/S boundary at lower doses, 0.1-5 microM, but induces apoptosis at higher doses, 10-25 microM, the effects of which were associated with selectively elevating protein levels of p53 and p21WAF1 in SK-HEP-1 cells. The cell growth suppressive and apoptosis inducing effects were confirmed by MTT assays together with flow cytometric analyses, morphological changes and DNA fragmentation. Immunoblotting showed that Ginsenoside Rs3 significantly elevated protein levels of p53 and p21WAF1 prior to inducing apoptosis, while it did not elevate those of cyclin E, cyclin A, p27Kip1, and PCNA. Immune complex kinase assays showed that Ginsenoside Rs3 downregulated the activities of both cyclins E- and A-associated kinases.

Synonyms	人参皂苷RS3
Molecular Weight	827.062
Formula	C44H74O14
CAS No.	194861-70-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Ginsenoside-Rs3, a new diol-type ginseng saponin, selectively elevates protein levels of p53 and p21WAF1 leading to induction of apoptosis in SK-HEP-1 cells.Anticancer Res. 1999 Jan-Feb;19(1A):487-91.

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Keywords

Ginsenoside Rs3 194861-70-6 凋亡 p53 Ginsenoside Rs-3 Inhibitor inhibitor inhibit

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