Powder: -20°C for 3 years | In solvent: -80°C for 1 year
K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
5 mg | In stock | $ 39.00 | |
10 mg | In stock | $ 72.00 | |
25 mg | In stock | $ 159.00 | |
50 mg | In stock | $ 288.00 | |
100 mg | In stock | $ 513.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner. |
Targets&IC50 | EG5:1.3 μM |
In vitro | K858 is an ATP-uncompetitive inhibitor of Eg5 that is at least 150-fold more selective for Eg5 than other members of the kinesin superfamily. K858 induces mitotic arrest and growth inhibition through the activation of the Mad2-mediated spindle checkpoint. K858 induces mitotic cell death in Y cells but not in normal cells. K858 induces mitotic arrest, apoptosis, and cell growth inhibition and has no effect on microtubule polymerization. |
In vivo | K858 exhibits antitumor activity and induces mitotic arrest in a human tumor xenograft mouse model. K858 exhibits antitumor activity and induces mitotic arrest in human xenograft tumor models. [1] |
Synonyms | K858 Racemic, K858 |
Molecular Weight | 277.34 |
Formula | C13H15N3O2S |
CAS No. | 72926-24-0 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 27.7 mg/mL(100 mM)
You can also refer to dose conversion for different animals. More
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