Kinesin|Targetmol

Kinesin

A kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule (MT) filaments, and are powered by the hydrolysis of adenosine triphosphate (ATP) (thus kinesins are ATPases). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo, such as in axonal transport.

Cat No.	product name
T1839	Mps1-IN-2	Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.
T2039	GSK923295	GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).
T2313	MPI-0479605	MPI-0479605 is an ATP competitive and selective inhibitor.
T2689	AZ 3146	AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.
T3118	Dimethylenastron	Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.
T3120	K858	K858 is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.
T4048	Monastrol	Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
T6393	ARQ 621	ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
T4649	Monastrol	Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.
TQ0314	EMD534085	EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).
T12434	PF-2771	PF-2771 is an inhibitor of centromere protein E (CENP-E)(IC50 of 16.1 nM).
T8487	Empesertib	Empesertib is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.
T14765	BOS-172722	BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint. With an IC50 of 2 nM.
T14906	CCT251455	CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).
T11155	Eg5 Inhibitor V, trans-24	Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 agonist inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.
T11859L	Litronesib	Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
T16152	Betamethasone 17-benzoate	Betamethasone 17-benzoate is a representative steroid. It also can be used in the treatment of recurrent aphothous ulcers (RAU).
T17007	TC-Mps1-12	TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .

Cat No.

product name

T1839

Mps1-IN-2

Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.

T2039

GSK923295

GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).

T2313

MPI-0479605

MPI-0479605 is an ATP competitive and selective inhibitor.

T2689

AZ 3146

AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.

T3118

Dimethylenastron

Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.

T3120

K858

K858 is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.

T4048

Monastrol

Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.

T6393

ARQ 621

ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.

T4649

Monastrol

Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.

TQ0314

EMD534085

EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).

T12434

PF-2771

PF-2771 is an inhibitor of centromere protein E (CENP-E)(IC50 of 16.1 nM).

T8487

Empesertib

Empesertib is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.

T14765

BOS-172722

BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint. With an IC50 of 2 nM.

T14906

CCT251455

CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).

T11155

Eg5 Inhibitor V, trans-24

Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 agonist inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.

T11859L

Litronesib

Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.

T16152

Betamethasone 17-benzoate

Betamethasone 17-benzoate is a representative steroid. It also can be used in the treatment of recurrent aphothous ulcers (RAU).

T17007

TC-Mps1-12

TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .