Kinesin

A kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule (MT) filaments, and are powered by the hydrolysis of adenosine triphosphate (ATP) (thus kinesins are ATPases). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo, such as in axonal transport.

Cat No.	product name
T12237	NMS-P715	NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
T8342	BRD9876	BRD9876 is a selective inhibitor of MM1S growth.
T2103	Ispinesib	Ispinesib, a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic properties.
T2039	GSK-923295	GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).
T2255	SB-743921 hydrochloride	SB-743921 is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).
T4048	Monastrol	Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
T2313	MPI-0479605	MPI-0479605 is an ATP competitive and selective inhibitor.
T6209	CW-069	CW069( IC50=75 μM）, an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
T36816	S-trityl-L-Cysteine	S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. ...
T12359	Paprotrain	Paprotrain is a cell-permeable the kinesin MKLP-2 inhibitor(inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM )
T1839	Mps1-IN-2	Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.
T3120	K858 (Racemic)	K858 is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.
T2689	AZ3146	AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.
T9207L	GW406108X(Z/E)	GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .
T9207	GW406108X	GW108X is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW837331X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block aut...
T8487	Empesertib	Empesertib is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.
T11859L	Litronesib	Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
T12434	PF-2771	PF-2771 is an inhibitor of centromere protein E (CENP-E)(IC50 of 16.1 nM).
T11155	Eg5 Inhibitor V, trans-24	Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 agonist inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.
TQ0314	EMD534085	EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).
T6393	ARQ 621	ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
T3434	BAY1217389	BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).
T3118	Dimethylenastron	Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.
T4649	Monastrol	Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
T17007	TC-Mps1-12	TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .
T16130	Mps1-IN-3	Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
T16152	Betamethasone 17-benzoate	Betamethasone 17-benzoate is a representative steroid. It also can be used in the treatment of recurrent aphothous ulcers (RAU).
T14765	BOS-172722	BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).
T14906	CCT251455	CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).