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Kinesin

A kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule (MT) filaments, and are powered by the hydrolysis of adenosine triphosphate (ATP) (thus kinesins are ATPases). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo, such as in axonal transport.
Cat No. product name
T12237 NMS-P715 NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
T8342 BRD9876 BRD9876 is a selective inhibitor of MM1S growth.
T2103 Ispinesib Ispinesib, a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic properties.
T2039 GSK-923295 GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).
T2255 SB-743921 hydrochloride SB-743921 is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).
T4048 Monastrol Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
T2313 MPI-0479605 MPI-0479605 is an ATP competitive and selective inhibitor.
T6209 CW-069 CW069( IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
T36816 S-trityl-L-Cysteine S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. ...
T12359 Paprotrain Paprotrain is a cell-permeable the kinesin MKLP-2 inhibitor(inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM )
T1839 Mps1-IN-2 Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.
T3120 K858 (Racemic) K858 is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.
T2689 AZ3146 AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.
T9207L GW406108X(Z/E) GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .
T9207 GW406108X GW108X is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW837331X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block aut...
T8487 Empesertib Empesertib is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.
T11859L Litronesib Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
T12434 PF-2771 PF-2771 is an inhibitor of centromere protein E (CENP-E)(IC50 of 16.1 nM).
T11155 Eg5 Inhibitor V, trans-24 Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 agonist inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.
TQ0314 EMD534085 EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).
T6393 ARQ 621 ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
T3434 BAY1217389 BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).
T3118 Dimethylenastron Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.
T4649 Monastrol Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
T17007 TC-Mps1-12 TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .
T16130 Mps1-IN-3 Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
T16152 Betamethasone 17-benzoate Betamethasone 17-benzoate is a representative steroid. It also can be used in the treatment of recurrent aphothous ulcers (RAU).
T14765 BOS-172722 BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).
T14906 CCT251455 CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).
NMS-P715
T12237
NMS-P715 is a selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).
BRD9876
T8342
BRD9876 is a selective inhibitor of MM1S growth.
Ispinesib
T2103
Ispinesib, a selective, effectvie and reversible inhibitor of kinesin spindle protein (KSP), is derived from quinazolinone, with antineoplastic properties.
GSK-923295
T2039
GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).
SB-743921 hydrochloride
T2255
SB-743921 is an effective inhibitor of kinesin spindle protein, KSP, (Ki =0.1 nM).
Monastrol
T4048
Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
MPI-0479605
T2313
MPI-0479605 is an ATP competitive and selective inhibitor.
CW-069
T6209
CW069( IC50=75 μM), an allosteric selective inhibitor of microtubule motor protein HSET, exhibits remarkable specificity over KSP.
S-trityl-L-Cysteine
T36816
S-trityl-L-Cysteine is a non-natural amino acid and an inhibitor of Eg5, also known as KSP and Kif11, a mitotic kinesin necessary for mitotic spindle formation. ...
Paprotrain
T12359
Paprotrain is a cell-permeable the kinesin MKLP-2 inhibitor(inhibits the ATPase activity of MKLP-2 with an IC50 of 1.35 μM and a Ki of 3.36 μM )
Mps1-IN-2
T1839
Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.
K858 (Racemic)
T3120
K858 is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.
AZ3146
T2689
AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.
GW406108X(Z/E)
T9207L
GW406108X(Z/E) is a mixture of different configurations of GW406108X, which is an inhibitor of Kinesin-12 and ULK1 .
GW406108X
T9207
GW108X is a Kif15 inhibitor with an IC50 of 0.82 uM in ATPase assays. GW837331X is also an ULK1 kinase inhibitor with pIC50 values of 6.37 (427 nM) and block aut...
Empesertib
T8487
Empesertib is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.
Litronesib
T11859L
Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
PF-2771
T12434
PF-2771 is an inhibitor of centromere protein E (CENP-E)(IC50 of 16.1 nM).
Eg5 Inhibitor V, trans-24
T11155
Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 agonist inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.
EMD534085
TQ0314
EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).
ARQ 621
T6393
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
BAY1217389
T3434
BAY 1217389 is an effective and selective inhibitor of the monopolar spindle 1 (MPS1) kinase (IC50<10 nM).
Dimethylenastron
T3118
Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.
Monastrol
T4649
Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
TC-Mps1-12
T17007
TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .
Mps1-IN-3
T16130
Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
Betamethasone 17-benzoate
T16152
Betamethasone 17-benzoate is a representative steroid. It also can be used in the treatment of recurrent aphothous ulcers (RAU).
BOS-172722
T14765
BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).
CCT251455
T14906
CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).