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Cytoskeletal Signaling Kinesin

Kinesin

A kinesin is a protein belonging to a class of motor proteins found in eukaryotic cells. Kinesins move along microtubule (MT) filaments, and are powered by the hydrolysis of adenosine triphosphate (ATP) (thus kinesins are ATPases). The active movement of kinesins supports several cellular functions including mitosis, meiosis and transport of cellular cargo, such as in axonal transport.
Cat No. product name
T1839 Mps1-IN-2 Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.
T2039 GSK923295 GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).
T2313 MPI-0479605 MPI-0479605 is an ATP competitive and selective inhibitor.
T2689 AZ 3146 AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.
T3118 Dimethylenastron Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.
T3120 K858 K858 is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.
T4048 Monastrol Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
T6393 ARQ 621 ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
T4649 Monastrol Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.
TQ0314 EMD534085 EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).
T12434 PF-2771 PF-2771 is an inhibitor of centromere protein E (CENP-E)(IC50 of 16.1 nM).
T8487 Empesertib Empesertib is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.
T14765 BOS-172722 BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint. With an IC50 of 2 nM.
T14906 CCT251455 CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).
T11155 Eg5 Inhibitor V, trans-24 Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 agonist inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.
T11859L Litronesib Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
T16152 Betamethasone 17-benzoate Betamethasone 17-benzoate is a representative steroid. It also can be used in the treatment of recurrent aphothous ulcers (RAU).
T17007 TC-Mps1-12 TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .
Mps1-IN-2
T1839CAS 1228817-38-6
Mps1-IN-2 is a potent, selective and ATP-competitive dual Mps1/Plk1 inhibitor.
GSK923295
T2039CAS 1088965-37-0
GSK923295 is a selective allosteric inhibitor of CENP-E kinesin motor ATPase(Ki=3.2 nM).
MPI-0479605
T2313CAS 1246529-32-7
MPI-0479605 is an ATP competitive and selective inhibitor.
AZ 3146
T2689CAS 1124329-14-1
AZ3146 is a selective Mps1 inhibitor with IC50 of ~35 nM.
Dimethylenastron
T3118CAS 863774-58-7
Dimethylenastron, an Eg5 inhibitor, arrests cells with monopolar spindles to which all chromosomes attach in a syntelic manner.
K858
T3120CAS 72926-24-0
K858 is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner.
Monastrol
T4048CAS 329689-23-8
Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5.
ARQ 621
T6393CAS 1095253-39-6
ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
Monastrol
T4649CAS 254753-54-3
Monastrol is a potent and cell-permeable inhibitor of the mitotic kinesin Eg5 with an IC50 value of 14 μM.
EMD534085
TQ0314CAS 858668-07-2
EMD534085 is an effective and selective mitotic kinesin-5 inhibitor (IC50: 8 nM).
PF-2771
T12434CAS
PF-2771 is an inhibitor of centromere protein E (CENP-E)(IC50 of 16.1 nM).
Empesertib
T8487CAS 1443763-60-7
Empesertib is an orally bioavailable and selective inhibitor Mps1(IC50 < 1 nM), with potential antineoplastic activity.
BOS-172722
T14765CAS 1578245-44-9
BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint. With an IC50 of 2 nM.
CCT251455
T14906CAS 1400284-80-1
CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).
Eg5 Inhibitor V, trans-24
T11155CAS 869304-55-2
Eg5 Inhibitor V, trans-24 is a specific and potent Eg5 agonist inhibitor that can be used in cancer research with an IC50 value of 0.65 uM.
Litronesib
T11859LCAS 910634-41-2
Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
Betamethasone 17-benzoate
T16152CAS 22298-29-9
Betamethasone 17-benzoate is a representative steroid. It also can be used in the treatment of recurrent aphothous ulcers (RAU).
TC-Mps1-12
T17007CAS 1206170-62-8
TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .