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Kif15-IN-1
🥰Excellent
Catalog No. T15661Cas No. 672926-32-8
Kif15-IN-1 is a kinesin family 15 (Kif15) inhibitor with antiproliferative activity and potential anticancer activity, which can be used to study gastric cancer.
Kif15-IN-1
🥰Excellent
Purity: 99.39%
Catalog No. T15661Cas No. 672926-32-8
Kif15-IN-1 is a kinesin family 15 (Kif15) inhibitor with antiproliferative activity and potential anticancer activity, which can be used to study gastric cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $499 | In Stock |
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Purity:99.39%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Kif15-IN-1 is a kinesin family 15 (Kif15) inhibitor with antiproliferative activity and potential anticancer activity, which can be used to study gastric cancer. |
| In vitro | Concentration response analysis using the MT gliding assay revealed that the IC50 was 203 nM, significantly lower than the previous study. Concentration response curve using the MT-gliding assay, developed from 5 concentrations of Kif15-IN-1, ranging from 30 to 0.1 µM. Kif15-IN-1 is a competitive ATP inhibitor. Double reciprocal Lineweaver-Burk plot of ATP titration using 5 µM Kif15-IN-1. An increase in KMATP was observed when the ATP concentration was varied in the presence of Kif15-IN-1, indicating that Kif15-IN-1 competes with ATP binding. [1] |
| Molecular Weight | 430.48 |
| Formula | C20H22N4O5S |
| Cas No. | 672926-32-8 |
| Smiles | [C@@H](C(NC=1SC(C(OCC)=O)=C(C)N1)=O)([C@H](C)C)N2C(=O)C=3C(NC2=O)=CC=CC3 |
| Relative Density. | 1.361 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: < 0.1 mg/mL (insoluble) DMSO: 80 mg/mL（185.84 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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