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AZD-4877

Catalog No. T9682Cas No. 758722-49-5
Alias AZD4877

AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and mediates apoptosis. AZD-4877 has antitumor activity and inhibits circulating peripheral blood mononuclear cells (PBMC).

AZD-4877

AZD-4877

Purity: 99.87%
Catalog No. T9682Alias AZD4877Cas No. 758722-49-5
AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and mediates apoptosis. AZD-4877 has antitumor activity and inhibits circulating peripheral blood mononuclear cells (PBMC).
Pack SizePriceAvailabilityQuantity
1 mg$243In Stock
5 mg$612In Stock
10 mg$953In Stock
25 mg$1,530In Stock
50 mg$1,980In Stock
100 mg$2,780In Stock
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Purity:99.87%
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Product Introduction

Bioactivity
Description
AZD-4877 is a potent spindle kinesin (Eg5) inhibitor with an IC50 value of 2 nM. AZD-4877 is an alternative configuration of Ispinesib that inhibits mitosis, induces the formation of a unipolar spindle phenotype, and mediates apoptosis. AZD-4877 has antitumor activity and inhibits circulating peripheral blood mononuclear cells (PBMC).
Targets&IC50
EG5:2 nM
AliasAZD4877
Chemical Properties
Molecular Weight503.66
FormulaC28H33N5O2S
Cas No.758722-49-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (109.2 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9855 mL9.9273 mL19.8547 mL99.2733 mL
5 mM0.3971 mL1.9855 mL3.9709 mL19.8547 mL
10 mM0.1985 mL0.9927 mL1.9855 mL9.9273 mL
20 mM0.0993 mL0.4964 mL0.9927 mL4.9637 mL
50 mM0.0397 mL0.1985 mL0.3971 mL1.9855 mL
100 mM0.0199 mL0.0993 mL0.1985 mL0.9927 mL

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