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MPI-0479605
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Purity:99.23%
MPI-0479605
Catalog No. T2313Cas No. 1246529-32-7
MPI-0479605 is an ATP competitive and selective inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $86 | In Stock | |
| 2 mg | $127 | In Stock | |
| 5 mg | $198 | In Stock | |
| 10 mg | $373 | In Stock | |
| 25 mg | $628 | In Stock | |
| 50 mg | $893 | In Stock | |
| 100 mg | $1,220 | In Stock | |
| 500 mg | $2,450 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | MPI-0479605 is an ATP competitive and selective inhibitor. |
| Targets&IC50 | Mps1:1.8 nM |
| Kinase Assay | In Vitro Kinase Assays and Selectivity Screening : To measure Mps1 activity, 25 ng of recombinant, full-length enzyme is incubated in reaction buffer (50 mM Tris-HCl pH 7.5, 10 mM MgCl2, 0.01% Triton X-100 and 5 μM Myelin basic protein (MBP)) containing vehicle (DMSO alone) or inhibitors. Forty μM ATP (2xKm) is added with 1 μCi [γ-33P]ATP and the reaction is incubated at room temperature for 45 minutes. Reactions are terminated with 3% phosphoric acid and transferred to P81 filter plates. Samples are washed in 1% phosphoric acid and 33P radioactivity is measured on a TopCount scintillation reader. In-house kinase assays are all carried out at 2xKm ATP concentrations. MPI-0479605 (500 nM) is also screened against a larger kinase panel. |
| Cell Research | Cells are treated for 3 or 7 days with various concentrations of MPI-0479605 and the GI50 is determined. Cell viability is measured with CellTiter-Glo. (Only for Reference) |
| Molecular Weight | 407.51 |
| Formula | C22H29N7O |
| Cas No. | 1246529-32-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | DMSO: 1 mg/ml, Sonication is recommended.  Ethanol: 2 mg/mL (4.9 mM), Heating is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
Ethanol
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