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BOS-172722

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Purity:99.79%

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COA HNMR HPLC

BOS-172722

Catalog No. T14765Cas No. 1578245-44-9

BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).

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Pack Size	Price	Availability
1 mg	$74	In Stock
5 mg	$178	In Stock
10 mg	$272	In Stock
25 mg	$547	In Stock
50 mg	$789	In Stock
100 mg	$1,080	In Stock
1 mL x 10 mM (in DMSO)	$198	In Stock

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Product Introduction

Bioactivity

Description	BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint(IC50 of 2 nM).
In vitro	BOS-172722 is an inhibitor of monopolar spindle 1 (MPS1) checkpoint with an IC50 of 2 nM and it also has potential for the treatment of various forms of breast cancer[1].

Chemical Properties

Molecular Weight	446.55
Formula	C24H30N8O
Cas No.	1578245-44-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

1M HCl: 65 mg/mL (145.56 mM)

DMSO: 5 mg/mL (11.20 mM)

Solution Preparation Table

1M HCl/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2394 mL	11.1970 mL	22.3939 mL	111.9695 mL
5 mM	0.4479 mL	2.2394 mL	4.4788 mL	22.3939 mL
10 mM	0.2239 mL	1.1197 mL	2.2394 mL	11.1970 mL

1M HCl

	1mg	5mg	10mg	50mg
20 mM	0.1120 mL	0.5598 mL	1.1197 mL	5.5985 mL
50 mM	0.0448 mL	0.2239 mL	0.4479 mL	2.2394 mL
100 mM	0.0224 mL	0.1120 mL	0.2239 mL	1.1197 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc