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Kinesore
🥰Excellent
Catalog No. T15663Cas No. 363571-83-9
Kinesore is a cell-permeable small molecule modulator that binds primarily to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 (kinesin light chain 2) and SKIP (SKIP protein), and thus regulating the structure of the microtubule network to influence cytoskeletal organization and dynamics.
Kinesore
🥰Excellent
Catalog No. T15663Cas No. 363571-83-9
Kinesore is a cell-permeable small molecule modulator that binds primarily to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 (kinesin light chain 2) and SKIP (SKIP protein), and thus regulating the structure of the microtubule network to influence cytoskeletal organization and dynamics.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $36 | In Stock | |
| 5 mg | $61 | In Stock | |
| 10 mg | $95 | In Stock | |
| 25 mg | $162 | In Stock | |
| 50 mg | $243 | In Stock | |
| 100 mg | $365 | In Stock | |
| 200 mg | $548 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $68 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Kinesore is a cell-permeable small molecule modulator that binds primarily to the microtubule motor protein kinesin-1, thereby inhibiting the interaction between KLC2 (kinesin light chain 2) and SKIP (SKIP protein), and thus regulating the structure of the microtubule network to influence cytoskeletal organization and dynamics. |
| In vitro | In cells treated with Kinesore, the microtubule network was completely reorganized into a series of rings and bundles. Lysosomal compartments were concentrated in the juxtanuclear region, where microtubules were relatively scarce. Kinesore (50 μM) was highly permeable to cells, with 95 ± 2.4% of cells showing a reorganized non-radial microtubule network. [1] |
| Molecular Weight | 536.17 |
| Formula | C20H16Br2N4O4 |
| Cas No. | 363571-83-9 |
| Smiles | O=C(C1=CC(Br)=C(C(Br)=C1)O)NN=CC2=C(C)N(C3=CC([N+]([O-])=O)=CC=C3)C(C)=C2 |
| Relative Density. | 1.71 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (186.51 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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