Shopping Cart

Remove All

Your shopping cart is currently empty

ARQ 621

Select Batch

Purity:98.38%

Resource Download

COA HPLC HNMR

ARQ 621

Catalog No. T6393Cas No. 1095253-39-6

ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$56	In Stock
2 mg	$84	In Stock
5 mg	$147	In Stock
10 mg	$213	In Stock
25 mg	$378	In Stock
50 mg	$546	In Stock
100 mg	$787	In Stock

Bulk & Custom

Add to Cart

Questions

Related Compound Libraries of "ARQ 621"

Product Introduction

Bioactivity

Description	ARQ 621 is an allosteric, and selective Eg5 mitotic motor protein inhibitor. Phase 1.
In vitro	ARQ 621 demonstrates anti-tumor activity against a wide range of human cancer cell lines in vitro, including colon, lung, endometrial, bladder, and hematologic cancer cell lines, with significantly less cytotoxicity against hematopoietic cells. [1]
In vivo	ARQ 621, as a novel clinical stage drug candidate, inhibits a number of xenografts grown in athymic mice, such as pancreatic, breast, prostate, and ovarian carcinomas with no hematological changes. Furthermore, for ARQ 621, there is no envidence of bone marrow toxicity in pre-clinical mouse efficacy models or safety studies in rats and dogs. [1]

Chemical Properties

Molecular Weight	552.43
Formula	C28H24Cl2FN5O2
Cas No.	1095253-39-6

Storage & Solubility Information

Storage

store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 93 mg/mL (168.3 mM)

DMSO: 93 mg/mL (168.3 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

Ethanol

	1mg	5mg	10mg	50mg
1 mM	1.8102 mL	9.0509 mL	18.1018 mL	90.5092 mL
5 mM	0.3620 mL	1.8102 mL	3.6204 mL	18.1018 mL
10 mM	0.1810 mL	0.9051 mL	1.8102 mL	9.0509 mL
20 mM	0.0905 mL	0.4525 mL	0.9051 mL	4.5255 mL
50 mM	0.0362 mL	0.1810 mL	0.3620 mL	1.8102 mL
100 mM	0.0181 mL	0.0905 mL	0.1810 mL	0.9051 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc