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TC-Mps1-12
Catalog No. T17007Cas No. 1206170-62-8
TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .
TC-Mps1-12
Catalog No. T17007Cas No. 1206170-62-8
TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) .
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $543 | 35 days | |
| 50 mg | $2,200 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | TC-Mps1-12 is an effective and selective inhibitor of monopolar spindle 1 (IC50: 6.4 nM) . |
| Targets&IC50 | Mps1:6.4 nM |
| In vitro | TC-Mps1-12 (72 hours) inhibits the growth of cells in a dose-dependent manner (IC50: 0.84 μM). TC-Mps1-12 inhibits the growth of pMps1 cell lines (IC50: 131 nM in autophosphorylation assay) [1]. |
| In vivo | TC-Mps1-12 (25-100 mg/kg; p.o.; daily; for 19 days) inhibits the growth of A549 cells dose-dependently in vivo. TC-Mps1-12 (100 mg/kg) achieves 47% tumor growth inhibition without body weight loss. TC-Mps1-12 (p.o., 25 mg/kg) displays good PK properties with a Cmax of 3542 ng/mL and AUC of 6604 ng·h/mL [1]. |
| Molecular Weight | 324.38 |
| Formula | C17H20N6O |
| Cas No. | 1206170-62-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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