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CCT251455
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Catalog No. T14906Cas No. 1400284-80-1
CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).
CCT251455
😃Good
Catalog No. T14906Cas No. 1400284-80-1
CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,820 | 8-10 weeks | |
| 50 mg | $2,380 | 8-10 weeks | |
| 100 mg | $3,100 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | CCT251455 is an inhibitor of mitotic kinase monopolar spindle 1 (MPS1; IC50: 3 nM). |
| Targets&IC50 | Mps1:3 nM |
| In vitro | CCT251455 is a highly potent and selective MPS1 inhibitor, demonstrating significant inhibition [versus other kinases] in extensive kinome profiling. It effectively inhibits P-MPS1 with an IC50 of 0.04 μM and a GI50 of 0.16 μM in cell-based assays. |
| In vivo | CCT251455 exhibits a favorable oral pharmacokinetic profile in mice and rats and effectively inhibits MPS1 activity in vivo following oral administration. |
| Molecular Weight | 503.98 |
| Formula | C26H26ClN7O2 |
| Cas No. | 1400284-80-1 |
| Relative Density. | 1.34 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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