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CCT251455

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Catalog No. T14906Cas No. 1400284-80-1
Alias CCT 251455

CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.

CCT251455

CCT251455

😃Good
Purity: 99.1%
Catalog No. T14906Alias CCT 251455Cas No. 1400284-80-1
CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.
Pack SizePriceAvailabilityQuantity
25 mg$1,820 8-10 weeks
50 mg$2,380 8-10 weeks
100 mg$3,100 8-10 weeks
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Purity:99.1%
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Product Introduction

Bioactivity
Description
CCT251455, the mitotic kinase monopolar spindle 1 (MPS1/TTK) inhibitor, is a potent (IC50=3 nM) and specific chemical tool.
Targets&IC50
MPS1:3 nM
In vitro
CCT251455 is a potent MPS1 inhibitor that exhibits high selectivity across a broad kinase profiling panel and excellent translation of in vitro biochemical potency to cellular potency compared to the isolated MPS1 enzyme (P-MPS1 IC50 of 0.04 μM and HCT116 GI50 of 0.16 μM).[1]
In vivo
Methods: Mice bearing HCT116 human colon cancer xenografts were treated with CCT251455 (50, 75, and 100 mg/kg, orally, twice daily).
Results: CCT251455 was well tolerated at all doses and inhibited MPS1 activity in mice; the observed reduction in phospho-histone H3 inhibition was consistent with the reduction in total plasma and tumor tissue exposure measured in the same experiment. [1]
AliasCCT 251455
Chemical Properties
Molecular Weight503.98
FormulaC26H26ClN7O2
Cas No.1400284-80-1
SmilesO=C(OC(C)(C)C)N1C=2C=C(N=CC2C=C1C=3C=NN(C3)C)NC=4C=CC(=CC4Cl)C5=CN=CN5C
Relative Density.1.34 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (198.42 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9842 mL9.9210 mL19.8421 mL99.2103 mL
5 mM0.3968 mL1.9842 mL3.9684 mL19.8421 mL
10 mM0.1984 mL0.9921 mL1.9842 mL9.9210 mL
20 mM0.0992 mL0.4961 mL0.9921 mL4.9605 mL
50 mM0.0397 mL0.1984 mL0.3968 mL1.9842 mL
100 mM0.0198 mL0.0992 mL0.1984 mL0.9921 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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