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Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | Inquiry | 8-10 weeks | |
50 mg | Inquiry | 8-10 weeks | |
100 mg | Inquiry | 8-10 weeks |
Description | Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity. |
In vitro | Litronesib (LY2523355) functions as a selective inhibitor of Eg5, promoting cancer cell death by inducing mitotic arrest at a concentration of 25 nM. This process requires the prolonged activation of the spindle-assembly checkpoint (SAC)[1]. |
In vivo | Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) displays antitumor activity in a dose-dependently. It also leads to a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors[1]. |
Alias | LY-2523355, KF-89617 |
Molecular Weight | 511.7 |
Formula | C23H37N5O4S2 |
Cas No. | 910634-41-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (97.71 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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