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Litronesib
😃Good
Catalog No. T11859LCas No. 910634-41-2
Alias LY-2523355, KF-89617
Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
Litronesib
😃Good
Catalog No. T11859LAlias LY-2523355, KF-89617Cas No. 910634-41-2
Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | Inquiry | 8-10 weeks | |
| 50 mg | Inquiry | 8-10 weeks | |
| 100 mg | Inquiry | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity. |
| In vitro | Litronesib (LY2523355) functions as a selective inhibitor of Eg5, promoting cancer cell death by inducing mitotic arrest at a concentration of 25 nM. This process requires the prolonged activation of the spindle-assembly checkpoint (SAC)[1]. |
| In vivo | Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) displays antitumor activity in a dose-dependently. It also leads to a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors[1]. |
| Alias | LY-2523355, KF-89617 |
| Molecular Weight | 511.7 |
| Formula | C23H37N5O4S2 |
| Cas No. | 910634-41-2 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (97.71 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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