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Litronesib

Catalog No. T11859LCas No. 910634-41-2
Alias LY-2523355, KF-89617

Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.

Litronesib

Litronesib

Catalog No. T11859LAlias LY-2523355, KF-89617Cas No. 910634-41-2
Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
Pack SizePriceAvailabilityQuantity
25 mgInquiry8-10 weeks
50 mgInquiry8-10 weeks
100 mgInquiry8-10 weeks
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Product Introduction

Bioactivity
Description
Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
In vitro
Litronesib (LY2523355) functions as a selective inhibitor of Eg5, promoting cancer cell death by inducing mitotic arrest at a concentration of 25 nM. This process requires the prolonged activation of the spindle-assembly checkpoint (SAC)[1].
In vivo
Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) displays antitumor activity in a dose-dependently. It also leads to a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors[1].
AliasLY-2523355, KF-89617
Chemical Properties
Molecular Weight511.7
FormulaC23H37N5O4S2
Cas No.910634-41-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (97.71 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.9543 mL9.7714 mL19.5427 mL97.7135 mL
5 mM0.3909 mL1.9543 mL3.9085 mL19.5427 mL
10 mM0.1954 mL0.9771 mL1.9543 mL9.7714 mL
20 mM0.0977 mL0.4886 mL0.9771 mL4.8857 mL
50 mM0.0391 mL0.1954 mL0.3909 mL1.9543 mL

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