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Litronesib

Catalog No. T11859LCas No. 910634-41-2

Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.

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Pack Size	Price	Availability
25 mg	Inquiry	8-10 weeks
50 mg	Inquiry	8-10 weeks
100 mg	Inquiry	8-10 weeks

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Product Introduction

Bioactivity

Description	Litronesib is a selective inhibitor of mitosis-specific kinesin Eg5. It also has antitumor activity.
In vitro	Litronesib (LY2523355) functions as a selective inhibitor of Eg5, promoting cancer cell death by inducing mitotic arrest at a concentration of 25 nM. This process requires the prolonged activation of the spindle-assembly checkpoint (SAC)[1].
In vivo	Litronesib (LY2523355; 1.1, 3.3, 10, and 30 mg/kg, i.v.) displays antitumor activity in a dose-dependently. It also leads to a dramatic increase in cancer cells immuno-positive for histone H3 phosphorylation in Colo205 xenograft tumors[1].
Alias	KF-89617, LY-2523355

Chemical Properties

Molecular Weight	511.7
Formula	C23H37N5O4S2
Cas No.	910634-41-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 50 mg/mL (97.71 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9543 mL	9.7714 mL	19.5427 mL	97.7135 mL
5 mM	0.3909 mL	1.9543 mL	3.9085 mL	19.5427 mL
10 mM	0.1954 mL	0.9771 mL	1.9543 mL	9.7714 mL
20 mM	0.0977 mL	0.4886 mL	0.9771 mL	4.8857 mL
50 mM	0.0391 mL	0.1954 mL	0.3909 mL	1.9543 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc