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Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $35 | In Stock | |
5 mg | $58 | In Stock | |
10 mg | $93 | In Stock | |
25 mg | $178 | In Stock | |
50 mg | $328 | In Stock | |
100 mg | $473 | In Stock | |
200 mg | $663 | In Stock | |
1 mL x 5 mM (in DMSO) | $68 | In Stock |
Description | Mps1-IN-3 is an effective and selective inhibitor of MPS1 kinase (IC50: 50 nM). |
Targets&IC50 | Mps1:50 nM |
In vitro | Mps1-IN-3 inhibits the proliferation of U251 glioblastoma cells (IC50: appr 5 μM). Mps1-IN-3 is an effective inhibitor of MPS1 kinase (IC50: 50 nM). Mps1-IN-3 (2 μM) can completely abrogates checkpoint. |
In vivo | Mps1-IN-3 (2 mg/kg, i.v.) enhances the sensitivity of glioblastoma cells in murine tumor models, extends survival, and exhibits no toxicity. |
Molecular Weight | 537.63 |
Formula | C26H31N7O4S |
Cas No. | 1609584-72-6 |
Smiles | COc1cc(ccc1Nc1nc(Nc2ccccc2S(=O)(=O)C(C)C)c2nc[nH]c2n1)N1CCC(O)CC1 |
Relative Density. | 1.407 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 60 mg/mL (111.6 mM), Sonication is recommended. ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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