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KB-5246

Catalog No. T11744 CAS 119474-55-4

KB-5246, displays antibacterial activities.is a tetracyclic quinolone.

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KB-5246, CAS 119474-55-4

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,670.00
50 mg	6-8 weeks	$ 2,180.00
100 mg	6-8 weeks	$ 2,800.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

Chemical Properties

Storage & Solubility Information

Description	KB-5246, displays antibacterial activities.is a tetracyclic quinolone.
In vitro	KB5246, a tetracyclic quinolone with antibacterial properties, effectively inhibits 90% of Escherichia coli, Klebsiella pneumoniae, and Klebsiella oxytoca isolates at concentrations of 0.10 μg/mL or lower. Notably, concentrations of KB-5246 at or above the minimum inhibitory concentration (MIC) prevent regrowth of these organisms after 24 hours of incubation. Additionally, the MICs for 90% of tested isolates (MIC90s) against key gram-positive microorganisms, including methicillin-resistant Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, and Streptococcus pyogenes, are 0.39 μg/mL, showcasing KB-5246's broad-spectrum antibacterial efficacy.
In vivo	The 50% effective dose (ED50) of KB-5246 for treating S. pneumoniae 2132 infections is 50.5 mg/kg. Its efficacy against S. aureus Smith, P. aeruginosa GN11189, and Serratia marcescens GN7577 is on par with ofloxacin and surpasses that of norfloxacin.

Molecular Weight	425.86
Formula	C18H17ClFN3O4S
CAS No.	119474-55-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Kotera Y, et al. In vitro and in vivo antibacterial activities of KB-5246, a new tetracyclic quinolone. Antimicrob Agents Chemother. 1989 Nov;33(11):1896-900.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

KB-5246 119474-55-4 GPCR/G Protein MAPK Ras KB 5246 KB5246 inhibitor inhibit

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