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Loxoribine

Catalog No. T15777 CAS 121288-39-9

Synonyms: RWJ 21757, 7-Allyl-8-oxoguanosine

Loxoribine (RWJ 21757) is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.

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Loxoribine, CAS 121288-39-9

Pack Size	Availability	Price/USD
5 mg	In stock	$ 43.00
10 mg	In stock	$ 70.00
25 mg	In stock	$ 116.00
50 mg	In stock	$ 172.00
100 mg	In stock	$ 255.00
1 mL * 10 mM (in DMSO)	In stock	$ 48.00

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Purity: 99.73%

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Storage & Solubility Information

Description	Loxoribine (RWJ 21757) is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.
In vitro	Loxoribine selectively activates innate immune system cells through the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway[1], leading to the maturation of human monocyte-derived dendritic cells (DCs) and enhancing their Th-1- and Th-17-polarizing capability[2]. Additionally, loxoribine (250 μM; 48 hours) promotes MoDCs maturation, evident from the increased expression of CD80, CD83, CD40, CD54, and CCR7[2].
In vivo	In vivo, Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells[3].

Synonyms	RWJ 21757, 7-Allyl-8-oxoguanosine
Molecular Weight	339.3
Formula	C13H17N5O6
CAS No.	121288-39-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (81.05 mM)

References and Literature

1. Heil F, et al. The Toll-like receptor 7 (TLR7)-specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily. Eur J Immunol. 2003 Nov;33(11):2987-97. 2. Dzopalic T, et al. Loxoribine, a selective Toll-like receptor 7 agonist, induces maturation of human monocyte-derived dendritic cells and stimulates their Th-1- and Th-17-polarizing capability. Int Immunopharmacol. 2010 Nov;10(11):1428-33. 3. Pope BL, et al. In vivo enhancement of murine natural killer cell activity by 7-allyl-8-oxoguanosine (loxoribine). Int J Immunopharmacol. 1992 Nov;14(8):1375-82.

Related compound libraries

This product is contained In the following compound libraries：

Membrane Protein-targeted Compound Library Anti-Cancer Active Compound Library Anti-Infection Compound Library Anti-Viral Compound Library ReFRAME Related Library Bioactive Compound Library Anti-Cancer Compound Library Human Metabolite Library Immuno-Oncology Compound Library Reprogramming Compound Library

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Keywords

Loxoribine 121288-39-9 Immunology/Inflammation Microbiology/Virology TLR Influenza Virus RWJ 21757 natural Toll-like Receptor (TLR) killer,cells Inhibitor RWJ-21757 RWJ21757 cells 7-Allyl-8-oxoguanosine inhibit TLR-7 MoDCs inhibitor

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