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TLR

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.
Cat No. product name
T0194 Chloroquine phosphate Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
T3898 Schaftoside Schaftoside has antioxidant and anticancer activity.
T12933 SM-276001 SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.
T9570 Enpatoran Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo....
T17032 Telratolimod Telratolimod is a toll-like receptors 7/8 agonist. It has an antitumor activity.
T0951 Hydroxychloroquine sulfate Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydrox...
T8689 Chloroquine Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and...
T0134 Imiquimod Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.
T6964 Resiquimod Resiquimod is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect thro...
TJS1779 Protosappanin A Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB inflammat...
T9287 Hydroxychloroquine Hydroxychloroquine (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It is a med...
T15777 Loxoribine Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activit...
T12516 Polyinosinic-polycytidylic acid sodium Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gen...
T6677 Sophocarpine Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T3826 Polygalasaponin F Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and re...
T6846 Vesatolimod GS-9620 is an effective and specific orally active agonist of Toll-like receptor 7.
TQ0181 Resatorvid Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 n...
T3795 Corilagin Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the ...
T5S0167 Atractylenolide I 1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reductio...
T8727 TH1020 TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.
T39669 TLR7/8/9-IN-1 TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.
T2S0265 Robinin Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of ...
T5S0045 Isofraxidin 1. Isofraxidin protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective...
T4080 Leonurine hydrochloride Leonurine (hydrochloride), a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
T5521 Bropirimine Bropirimine (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.
T35349 CU-CPD107 CU-CPD107是一种选择性的双活性小分子,对TLR8激动剂和ssRNA配体表现出不同的活性。在R848存在的情况下,CU-CPD107是TLR8信号抑制剂 (IC50=13.7 μM)。在ssRNA存在的情况下,CU-CPD107表现出协同激动剂活性,而CU-CPD107单独不能影响TLR8信号转导。
TP1938 RS 09 TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enh...
T2911 Stevioside A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anion...
T23171 Polyinosinic-polycytidylic acid Poly (I:C) is a synthetic double-stranded RNA (dsRNA) analog and is an immunostimulant that acts as the most potent interferon (IFN) inducer. It also is a Toll-l...
T22698 TLR3-IN-1 CU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit ...
TN1936 Mogroside III-E Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in...
TN2008 Okanin Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
T8316 1V209 1V209 is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
T8503 TLR4-IN-C34 TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis
T7860 SM-324405 SM 324405 is an agonist of TLR7.
T7672 MD2-TLR4-IN-1 MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.
T7347 CU-CPT-8m CU-CPT-8m is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
T7317 CU-CPT-9a CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-
T7302 CU-CPT9b CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HE...
T10437 AZD8848 AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
T10899 CU-CPT17e CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).
T10833 CL264 CL264, a specific agonist of TLR7, is used for innate immune signals research.
T11598 IAXO-102 IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflam...
T13182 Toll-like receptor modulator Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
T13168 TLR7 agonist 1 TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).
T13167 TLR7/8 agonist 3 TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.
TN3587 Capillarisin Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN4171 Grossamide Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
TN5138 Teuclatriol Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 312...
TP1938L RS09 2TFA (1449566-36-2 free base) RS09 2TFA is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. It acts as an ad...
Chloroquine phosphate
T0194
Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
Schaftoside
T3898
Schaftoside has antioxidant and anticancer activity.
SM-276001
T12933
SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.
Enpatoran
T9570
Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo....
Telratolimod
T17032
Telratolimod is a toll-like receptors 7/8 agonist. It has an antitumor activity.
Hydroxychloroquine sulfate
T0951
Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydrox...
Chloroquine
T8689
Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and...
Imiquimod
T0134
Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.
Resiquimod
T6964
Resiquimod is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect thro...
Protosappanin A
TJS1779
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infla...
Hydroxychloroquine
T9287
Hydroxychloroquine (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It is a med...
Loxoribine
T15777
Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activit...
Polyinosinic-polycytidylic acid sodium
T12516
Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gen...
Sophocarpine
T6677
Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
Polygalasaponin F
T3826
Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and r...
Vesatolimod
T6846
GS-9620 is an effective and specific orally active agonist of Toll-like receptor 7.
Resatorvid
TQ0181
Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 n...
Corilagin
T3795
Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the ...
Atractylenolide I
T5S0167
1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reducti...
TH1020
T8727
TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.
TLR7/8/9-IN-1
T39669
TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.
Robinin
T2S0265
Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of ...
Isofraxidin
T5S0045
1. Isofraxidin protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective...
Leonurine hydrochloride
T4080
Leonurine (hydrochloride), a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
Bropirimine
T5521
Bropirimine (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.
CU-CPD107
T35349
CU-CPD107是一种选择性的双活性小分子,对TLR8激动剂和ssRNA配体表现出不同的活性。在R848存在的情况下,CU-CPD107是TLR8信号抑...
RS 09
TP1938
TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; en...
Stevioside
T2911
A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anion...
Polyinosinic-polycytidylic acid
T23171
Poly (I:C) is a synthetic double-stranded RNA (dsRNA) analog and is an immunostimulant that acts as the most potent interferon (IFN) inducer. It also is a Toll-l...
TLR3-IN-1
T22698
CU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit...
Mogroside III-E
TN1936
Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in...
Okanin
TN2008
Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
1V209
T8316
1V209 is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
TLR4-IN-C34
T8503
TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis
SM-324405
T7860
SM 324405 is an agonist of TLR7.
MD2-TLR4-IN-1
T7672
MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.
CU-CPT-8m
T7347
CU-CPT-8m is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
CU-CPT-9a
T7317
CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-
CU-CPT9b
T7302
CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HE...
AZD8848
T10437
AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
CU-CPT17e
T10899
CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).
CL264
T10833
CL264, a specific agonist of TLR7, is used for innate immune signals research.
IAXO-102
T11598
IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinfla...
Toll-like receptor modulator
T13182
Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
TLR7 agonist 1
T13168
TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).
TLR7/8 agonist 3
T13167
TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.
Capillarisin
TN3587
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
Grossamide
TN4171
Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
Teuclatriol
TN5138
Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of 3...
RS09 2TFA (1449566-36-2 free base)
TP1938L
RS09 2TFA is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. It acts as an a...
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