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Immunology / Inflammation TLR

TLR

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.
Cat No. product name
T0134 Imiquimod Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.
T0951 Hydroxychloroquine sulfate Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydro...
T2911 Stevioside A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anio...
T3502 C29 C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 sign...
T4068 E6446 dihydrochloride E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
T4080 Leonurine hydrochloride Leonurine (hydrochloride), a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
T4206 E6446 E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. Whe...
T4231 MD2-IN-1 MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2).
T6846 Vesatolimod GS-9620 is an effective and specific orally active agonist of Toll-like receptor 7.
T6898 Motolimod Motolimod (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.
T6964 Resiquimod Resiquimod is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect thr...
T4258 TLR7-agonist-1 TLR7-agonist-1 is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
T5561 TLR7/8 agonist 1 dihydrochloride TLR7/8 agonist 1 is a TLR7/8 agonist which shows prominent immunostimulatory activities.
T7317 CU-CPT-9a CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-
T7302 CU-CPT9b CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing H...
T7347 CU-CPT-8m CU-CPT-8m is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
T7672 MD2-TLR4-IN-1 MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.
TQ0181 Resatorvid Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 ...
TQ0205 Procyanidin B1 Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.
T7860 SM 324405 SM 324405 is an  agonist of TLR7.
T8316 1V209 1V209  is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
TN1068 Tricin Tricin is evaluated as a type of tyrosinase inhibitor
TN1936 Mogroside IIIe Mogroside IIIe has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis via AM...
T10899 CU-CPT17e CU-CPT17e can activate TLR3, TLR8 and TLR9 and is a potent multi-Toll-like receptor (TLR) agonist.
T14035 3M-011 3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer, it is also a potent adjuvant to radiotherapy that induces local and profound s...
T14513 BBIQ BBIQ is a powerful vaccine adjuvant that enhances innate immune responses[1][2] and it is a imidazoquinoline compound and a potent and selectively toll-like rec...
TN2008 Okanin Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
T15017 CU-T12-9 CU-T12-9 is a specific agonist of TLR1/2 (EC50: 52.9 nM in HEK-Blue hTLR2 SEAP assay). It selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 sig...
T15371 Gardiquimod Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection ...
T12933 SM-276001 SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.
T10437 AZD8848 AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
T11598 IAXO-102 IAXO-102 also prevents experimental abdominal aortic aneurysm development. IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. It inhibi...
T13167 TLR7/8 agonist 3 TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.
T13168 TLR7 agonist 1 TLR7 agonist 1 is a potent, selective and oral TLR7 agonist with an IC50 of 90 nM.
T13182 Toll-like receptor modulator Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
T10833 CL264 CL264, a specific agonist of TLR7, is used for innate immune signals research.
T15751 LHC-165 LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.
T15785 LPA1 antagonist 1 LPA1 antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist (IC50: 25 nM).
T16136 MRS-1706 MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1, and A3 receptors respectively. MRS-1706 is an effective and selective adenosine A2B...
T16506 PF-4878691 PF-4878691 is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.
T16870 Selgantolimod Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
TJS1779 Protosappanin A Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infl...
TN3587 Capillarisin Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cel...
TN4171 Grossamide Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflamma...
TN5138 Teuclatriol Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of ...
Imiquimod
T0134CAS 99011-02-6
Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.
Hydroxychloroquine sulfate
T0951CAS 747-36-4
Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydro...
Stevioside
T2911CAS 57817-89-7
A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anio...
C29
T3502CAS 363600-92-4
C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 sign...
E6446 dihydrochloride
T4068CAS 1345675-25-3
E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
Leonurine hydrochloride
T4080CAS 24735-18-0
Leonurine (hydrochloride), a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
E6446
T4206CAS 1219925-73-1
E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. Whe...
MD2-IN-1
T4231CAS 111797-22-9
MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2).
Vesatolimod
T6846CAS 1228585-88-3
GS-9620 is an effective and specific orally active agonist of Toll-like receptor 7.
Motolimod
T6898CAS 926927-61-9
Motolimod (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.
Resiquimod
T6964CAS 144875-48-9
Resiquimod is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect thr...
TLR7-agonist-1
T4258CAS 1642857-69-9
TLR7-agonist-1 is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
TLR7/8 agonist 1 dihydrochloride
T5561CAS 1620278-72-9
TLR7/8 agonist 1 is a TLR7/8 agonist which shows prominent immunostimulatory activities.
CU-CPT-9a
T7317CAS 2165340-32-7
CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-
CU-CPT9b
T7302CAS 2162962-69-6
CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing H...
CU-CPT-8m
T7347CAS 125079-83-6
CU-CPT-8m is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
MD2-TLR4-IN-1
T7672CAS 2249801-12-3
MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.
Resatorvid
TQ0181CAS 243984-11-4
Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 ...
Procyanidin B1
TQ0205CAS 20315-25-7
Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.
SM 324405
T7860CAS 677773-91-0
SM 324405 is an  agonist of TLR7.
1V209
T8316CAS 1062444-54-5
1V209  is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
Tricin
TN1068CAS 520-32-1
Tricin is evaluated as a type of tyrosinase inhibitor
Mogroside IIIe
TN1936CAS 88901-37-5
Mogroside IIIe has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis via AM...
CU-CPT17e
T10899CAS 2109805-75-4
CU-CPT17e can activate TLR3, TLR8 and TLR9 and is a potent multi-Toll-like receptor (TLR) agonist.
3M-011
T14035CAS 642473-62-9
3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer, it is also a potent adjuvant to radiotherapy that induces local and profound s...
BBIQ
T14513CAS 1229024-57-0
BBIQ is a powerful vaccine adjuvant that enhances innate immune responses[1][2] and it is a imidazoquinoline compound and a potent and selectively toll-like rec...
Okanin
TN2008CAS 484-76-4
Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
CU-T12-9
T15017CAS 1821387-73-8
CU-T12-9 is a specific agonist of TLR1/2 (EC50: 52.9 nM in HEK-Blue hTLR2 SEAP assay). It selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 sig...
Gardiquimod
T15371CAS 1020412-43-4
Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection ...
SM-276001
T12933CAS 473930-22-2
SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.
AZD8848
T10437CAS 866269-28-5
AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
IAXO-102
T11598CAS 1115270-63-7
IAXO-102 also prevents experimental abdominal aortic aneurysm development. IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. It inhibi...
TLR7/8 agonist 3
T13167CAS 642473-95-8
TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.
TLR7 agonist 1
T13168CAS 2178156-33-5
TLR7 agonist 1 is a potent, selective and oral TLR7 agonist with an IC50 of 90 nM.
Toll-like receptor modulator
T13182CAS 926927-42-6
Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
CL264
T10833CAS 1510712-69-2
CL264, a specific agonist of TLR7, is used for innate immune signals research.
LHC-165
T15751CAS 1258595-14-0
LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.
LPA1 antagonist 1
T15785CAS 1396006-71-5
LPA1 antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist (IC50: 25 nM).
MRS-1706
T16136CAS 264622-53-9
MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1, and A3 receptors respectively. MRS-1706 is an effective and selective adenosine A2B...
PF-4878691
T16506CAS 532959-63-0
PF-4878691 is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.
Selgantolimod
T16870CAS 2004677-13-6
Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
Protosappanin A
TJS1779CAS 102036-28-2
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infl...
Capillarisin
TN3587CAS 56365-38-9
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cel...
Grossamide
TN4171CAS 80510-06-1
Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflamma...
Teuclatriol
TN5138CAS 152110-17-3
Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of ...