TLR

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.

Cat No.	product name
T0134	Imiquimod	Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.
T0951	Hydroxychloroquine sulfate	Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydro...
T2911	Stevioside	A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anio...
T3502	C29	C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 sign...
T4068	E6446 dihydrochloride	E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM.
T4080	Leonurine hydrochloride	Leonurine (hydrochloride), a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
T4206	E6446	E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. Whe...
T4231	MD2-IN-1	MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2).
T6846	Vesatolimod	GS-9620 is an effective and specific orally active agonist of Toll-like receptor 7.
T6898	Motolimod	Motolimod (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7.
T6964	Resiquimod	Resiquimod is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect thr...
T4258	TLR7-agonist-1	TLR7-agonist-1 is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM).
T5561	TLR7/8 agonist 1 dihydrochloride	TLR7/8 agonist 1 is a TLR7/8 agonist which shows prominent immunostimulatory activities.
T7317	CU-CPT-9a	CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-
T7302	CU-CPT9b	CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF-ĸB induced by the TLR8 agonist R-848 in TLR8-overexpressin...
T7347	CU-CPT-8m	CU-CPT-8m is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
T7672	MD2-TLR4-IN-1	MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.
TQ0181	Resatorvid	Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 ...
TQ0205	Procyanidin B1	Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity.
T7860	SM 324405	SM 324405 is an agonist of TLR7.
T8316	1V209	1V209 is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
TN1068	Tricin	Tricin is evaluated as a type of tyrosinase inhibitor
TN1936	Mogroside IIIe	Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury ...
T10899	CU-CPT17e	CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).
T14035	3M-011	3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer, it is also a potent adjuvant to radiotherapy that induces local and profound s...
T14513	BBIQ	BBIQ is a powerful vaccine adjuvant that enhances innate immune responses[1][2] and it is a imidazoquinoline compound and a potent and selectively toll-like rec...
TN2008	Okanin	Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
T15017	CU-T12-9	CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokin...
T15371	Gardiquimod	Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection ...
T12933	SM-276001	SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.
T10437	AZD8848	AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
T11598	IAXO-102	IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinfl...
T13167	TLR7/8 agonist 3	TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.
T13168	TLR7 agonist 1	TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).
T13182	Toll-like receptor modulator	Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
T10833	CL264	CL264, a specific agonist of TLR7, is used for innate immune signals research.
T15751	LHC-165	LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.
T15785	LPA1 antagonist 1	LPA1 antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist (IC50: 25 nM).
T16136	MRS-1706	MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1, and A3 receptors respectively. MRS-1706 is an effective and selective adenosine A2B...
T16506	PF-4878691	PF-4878691 is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities.
T16870	Selgantolimod	Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
TJS1779	Protosappanin A	Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB infl...
TN3587	Capillarisin	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cel...
TN4171	Grossamide	Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflamma...
TN5138	Teuclatriol	Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-ÎºB signaling at doses of ...
T8689	CHLOROQUINE	Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria an...
TP1067	Pam3CSK4 TFA (112208-00-1 free base)	Pam3CSK4 TFA is an agonist of toll-like receptor 1/2 (TLR1/2) (EC50 of 0.47 ng/mL for human TLR1/2).
T12516	Polyinosinic-polycytidylic acid sodium	Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible ge...
T0194	Chloroquine diphosphateHOT	Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
T23171	Poly(I:C)	Poly (I:C) is a synthetic double-stranded RNA (dsRNA) analog and is an immunostimulant that acts as the most potent interferon (IFN) inducer. It also is a Toll-...
T15777	Loxoribine	Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activi...
T8503	TLR4-IN-C34	TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis
T15020	CU-CPT22	CU-CPT22 is the first probe for the complex between toll-like receptors TLR1 and TLR2. CU-CPT22 binds at the interface of TLR1 and TLR2 (IC50 = 0.58 μM). It ...
TP1938L	RS09 2TFA 1449566-36-2(free base)	RS09 2TFA is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. It acts as ...