TLR

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.

Cat. No.	Product name	CAS No.	Purity
T39115	ABR-238901	1638200-22-2	98%
T39115	ABR-238901 is an oral, active S100A8/A9 blocker that inhibits the interaction of S100A8/A9 with its receptors RAGE(receptor for advanced glycation end products) ...
T34249	Rabeximod	872178-65-9	98%
T34249	Rabeximod is a potent immunomodulator that reduces the severity of autoimmune diseases in rat models. Rabeximod inhibits arthritis in a time-dependent manner by ...
T13182	Toll-like receptor modulator	926927-42-6	98%
T13182	Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
TN3587	Capillarisin	56365-38-9	98%
TN3587	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN4171	Grossamide	80510-06-1	98%
TN4171	Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
TP1938	RS 09	1449566-36-2	98%
TP1938	TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enh...
T10437	AZD8848	866269-28-5	98%
T10437	AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
T13168	TLR7 agonist 1	2178156-33-5	98%
T13168	TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).
T16870	Selgantolimod	2004677-13-6	98%
T16870	Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection.
T14035	3M-011	642473-62-9	98%
T14035	3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer, it is also a potent adjuvant to radiotherapy that induces local and profound sy...
T15785	LPA1 receptor antagonist 1	1396006-71-5	98%
T15785	LPA1 antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist (IC50: 25 nM).
T27034	CL075	256922-53-9	98%
T27034	CL075 is a selective TLR8 agonist.CL075 has immunomodulatory activity by triggering the MyD88-dependent signaling pathway, activating NF-κB and IRF7 to elicit th...
T72035	TLR7/8/9 antagonist 2	2920729-91-3	98%
T72035	TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. TLR7/8/9 antagonist 2 inhibits HEK/hTLR7, HEK/hTLR8 and HEK/hTLR9 with IC...
TN5138	Teuclatriol	152110-17-3	98%
TN5138	Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-ÎºB signaling at doses of 312...
T15751	LHC-165	1258595-14-0	98%
T15751	LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors.
T4206	E6446	1219925-73-1	98%
T4206	E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. When...
T15017	CU-T12-9	1821387-73-8	98%
T15017	CU-T12-9 is a potent TLR1/2 agonist(EC50 of 52.9 nM in HEK-Blue hTLR2 SEAP assay). It acts by activating the NFkB pathway, upregulating proinflammatory cytokines...
T13167	TLR7/8 agonist 3	642473-95-8	98%
T13167	TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.
T0951	Hydroxychloroquine sulfate	747-36-4	98%
T0951	Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydrox...
T6964	Resiquimod	144875-48-9	98%
T6964	Resiquimod is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect thro...