TLR

Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single-pass membrane-spanning receptors usually expressed on sentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes.

Cat No.	product name
T0194	Chloroquine phosphate	Chloroquine is an aminoquinoline antimalarial and also is widely used as an autophagy inhibitor. Chloroquine also is an inhibitor of toll-like receptors (TLRs).
T3898	Schaftoside	Schaftoside has antioxidant and anticancer activity.
T12933	SM-276001	SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer.
T9570	Enpatoran	Enpatoran is an inhibitor of TLR7(IC50 = 11.1 nM) and TLR8(IC50 = 24.1 nM). Enpatoran was found to be inactive against TLR3, TLR4, and TLR9 in vitro and in vivo....
T17032	Telratolimod	Telratolimod is a toll-like receptors 7/8 agonist. It has an antitumor activity.
T0951	Hydroxychloroquine sulfate	Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydrox...
T8689	Chloroquine	Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and...
T0134	Imiquimod	Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist.
T6964	Resiquimod	Resiquimod is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect thro...
TJS1779	Protosappanin A	Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IÎºB/NF-ÎºB inflammat...
T9287	Hydroxychloroquine	Hydroxychloroquine (HCQ) is an alkalinizing lysosomatropic drug that acts by inducing apoptosis of renal cancer cells in vitro and inhibiting TLR7/9. It is a med...
T15777	Loxoribine	Loxoribine is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activit...
T12516	Polyinosinic-polycytidylic acid sodium	Polyinosinic-polycytidylic acid sodium is a synthetic analog of double-stranded RNA and an agonist of toll-like receptor 3 (TLR3) and retinoic acid inducible gen...
T6677	Sophocarpine	Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects.
T3826	Polygalasaponin F	Polygalasaponin F has anti-neuroinflammatory activity, can inhibit the release of inflammatory cytokines TNF-α and NO induced by lipopolysaccharides (LPS) and re...
T6846	Vesatolimod	GS-9620 is an effective and specific orally active agonist of Toll-like receptor 7.
TQ0181	Resatorvid	Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 n...
T3795	Corilagin	Corilagin has anti-inflammatory activity. Corilagin has a significant antitumour potential and lower toxicity in normal cells in vitro.Corilagin can enhance the ...
T5S0167	Atractylenolide I	1. Atractylenolide-I has an anti-inflammatory effect by inhibiting TNF-α and IL-6 production; ameliorates sepsis syndrome, liver and kidney functions by reductio...
T8727	TH1020	TH1020 is a novel Inhibitor of Toll-Like Receptor 5 (TLR5)/Flagellin Complex with promising activity (IC50 =0.85±0.12 μm) and specificity.
T39669	TLR7/8/9-IN-1	TLR7/8/9-IN-1 is a potent inhibitor of Toll-like receptors 7/8/9 (TLR7/8/9) with an IC50 of 43 nM.
T2S0265	Robinin	Flavone glycoside from Robinia with antibacterial and diuretic properties; derived from kaempferol.The ability of robinin to reverse the multidrug resistance of ...
T5S0045	Isofraxidin	1. Isofraxidin protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective...
T4080	Leonurine hydrochloride	Leonurine (hydrochloride), a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles.
T5521	Bropirimine	Bropirimine (U-54461) is a biological response modifier that is thought to act through the induction of lymphokines.
T35349	CU-CPD107	CU-CPD107是一种选择性的双活性小分子，对TLR8激动剂和ssRNA配体表现出不同的活性。在R848存在的情况下，CU-CPD107是TLR8信号抑制剂 (IC50=13.7 μM)。在ssRNA存在的情况下，CU-CPD107表现出协同激动剂活性，而CU-CPD107单独不能影响TLR8信号转导。
TP1938	RS 09	TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. Acts as an adjuvant in vivo; enh...
T2911	Stevioside	A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anion...
T23171	Polyinosinic-polycytidylic acid	Poly (I:C) is a synthetic double-stranded RNA (dsRNA) analog and is an immunostimulant that acts as the most potent interferon (IFN) inducer. It also is a Toll-l...
T22698	TLR3-IN-1	CU CPT 4a is a selective TLR3 inhibitor (IC50: 3.44 μM in RAW 264.7 cells). It can inhibit TLR3/dsRNA complex-mediated downstream signaling pathways and inhibit ...
TN1936	Mogroside III-E	Mogroside III-E is a cucurbitane-type compound isolated from Siraitia grosvenorii, has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in...
TN2008	Okanin	Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect.
T8316	1V209	1V209 is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects.
T8503	TLR4-IN-C34	TLR4-IN-C34 is an inhibitor of TLR4, and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis
T7860	SM-324405	SM 324405 is an agonist of TLR7.
T7672	MD2-TLR4-IN-1	MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor.
T7347	CU-CPT-8m	CU-CPT-8m is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
T7317	CU-CPT-9a	CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells-
T7302	CU-CPT9b	CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing HE...
T10437	AZD8848	AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
T10899	CU-CPT17e	CU-CPT17e is a potent agonist of TLR(TLR3, TLR8, and TLR9).
T10833	CL264	CL264, a specific agonist of TLR7, is used for innate immune signals research.
T11598	IAXO-102	IAXO-102 is a TLR4 antagonist that negatively regulates TLR4 signaling. It inhibits MAPK and p65 NF-κB phosphorylation and expression of TLR4 dependent proinflam...
T13182	Toll-like receptor modulator	Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function.
T13168	TLR7 agonist 1	TLR7 agonist 1 is a selective and oral TLR7 agonist (IC50: 90 nM).
T13167	TLR7/8 agonist 3	TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8.
TN3587	Capillarisin	Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cell...
TN4171	Grossamide	Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflammat...
TN5138	Teuclatriol	Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-ÎºB signaling at doses of 312...
TP1938L	RS09 2TFA (1449566-36-2 free base)	RS09 2TFA is a TLR4 agonist. Promotes NF-κB nuclear translocation and induces inflammatory cytokine secretion in RAW264.7 macrophages in vitro. It acts as an ad...