T0134 |
Imiquimod |
Imiquimod is an immune response modifier that acts as a toll-like receptor 7 agonist. |
T0951 |
Hydroxychloroquine sulfate |
Hydroxychloroquine sulfate inhibits plasmodial heme polymerase. It is a chemotherapeutic agent that acts against erythrocytic forms of malarial parasites. Hydro...
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T2911 |
Stevioside |
A natural, noncaloric sweetener with a potency 300 times more than that of regular sucrose. Exhibits transepithelial p-aminohippurate transport via organic anio...
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T3502 |
C29 |
C29 is a novel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 sign...
|
T4068 |
E6446 dihydrochloride |
E6446 dihydrochloride is a novel synthetic antagonist for nucleic acid-sensing TLRs; potently suppressed DNA stimulation of HEK:TLR9 cells with IC50 of 10 nM. |
T4080 |
Leonurine hydrochloride |
Leonurine (hydrochloride), a major alkaloid compound extracted from Leonurus japonicas Houtt. (Labiatae), is considered to have antitumor roles. |
T4206 |
E6446 |
E6446 inhibits Toll-like receptor (TLR)7 and 9 signaling. E6446 works in a variety of human and mouse cell types and inhibits DNA-TLR9 interaction in vitro. Whe...
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T4231 |
MD2-IN-1 |
MD2-IN-1 is an inhibitor of Myeloid differentiation protein 2 (MD2) with a KD of 189 μM for the recombinant human MD2 (rhMD2). |
T6846 |
Vesatolimod |
GS-9620 is an effective and specific orally active agonist of Toll-like receptor 7. |
T6898 |
Motolimod |
Motolimod (VTX-2337) is an effective and specific Toll-like receptor (TLR) 8 agonist (EC50: 100 nM), > 50-fold selectivity over TLR7. |
T6964 |
Resiquimod |
Resiquimod is an imidazoquinoline amine and Toll-like receptor (TLR) agonist with potential immune response modifying activity. Resiquimod exerts its effect thr...
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T4258 |
TLR7-agonist-1 |
TLR7-agonist-1 is a specific and effective Toll-like Receptor 7 (TLR7) agonist (LEC=0.4 μM). |
T5561 |
TLR7/8 agonist 1 dihydrochloride |
TLR7/8 agonist 1 is a TLR7/8 agonist which shows prominent immunostimulatory activities. |
T7317 |
CU-CPT-9a |
CU-CPT-9a is a potent TLR8 inhibitor (IC50 : 0.5 nM), that suppresses TLR8-mediated proinflammatory signaling in various cell lines and human primary cells- |
T7302 |
CU-CPT9b |
CU-CPT9b is an antagonist of toll-like receptor 8 (TLR8; Kd = 21 nM). It inhibits activation of NF- B induced by the TLR8 agonist R-848 in TLR8-overexpressing H...
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T7347 |
CU-CPT-8m |
CU-CPT-8m is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM) |
T7672 |
MD2-TLR4-IN-1 |
MD2-TLR4-IN-1 is a myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex inhibitor. |
TQ0181 |
Resatorvid |
Resatorvid (TAK-242) is a selective inhibitor of Toll-like receptor 4 (TLR4). Resatorvid inhibits IL-6, TNF-R and NO production (IC50s: 1.3 nM, 1.9 nM, and 1.8 ...
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TQ0205 |
Procyanidin B1 |
Procyanidin B1, isolated from commonly eaten fruits, binds to the TLR4/MD-2 complex and has anti-inflammatory activity. |
T7860 |
SM 324405 |
SM 324405 is an agonist of TLR7. |
T8316 |
1V209 |
1V209 is a Toll-like receptor 7 (TLR7) agonist and has anti-tumor effects. |
TN1068 |
Tricin |
Tricin is evaluated as a type of tyrosinase inhibitor |
TN1936 |
Mogroside IIIe |
Mogroside IIIe has anti-inflammatory activity, it attenuates LPS-induced acute lung injury in mice partly through regulation of the TLR4/MAPK/NF-κB axis via AM...
|
T10899 |
CU-CPT17e |
CU-CPT17e can activate TLR3, TLR8 and TLR9 and is a potent multi-Toll-like receptor (TLR) agonist. |
T14035 |
3M-011 |
3M-011 is a potent dual toll-like receptor TLR7/8 agonist and a cytokine inducer, it is also a potent adjuvant to radiotherapy that induces local and profound s...
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T14513 |
BBIQ |
BBIQ is a powerful vaccine adjuvant that enhances innate immune responses[1][2] and it is a imidazoquinoline compound and a potent and selectively toll-like rec...
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TN2008 |
Okanin |
Okanin shows significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect. |
T15017 |
CU-T12-9 |
CU-T12-9 is a specific agonist of TLR1/2 (EC50: 52.9 nM in HEK-Blue hTLR2 SEAP assay). It selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 sig...
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T15371 |
Gardiquimod |
Gardiquimod is a TLR7/8 agonist. When used at concentrations below 10 μM, Gardiquimod specifically activates TLR7. Gardiquimod could inhibit HIV-1 infection ...
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T12933 |
SM-276001 |
SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer. |
T10437 |
AZD8848 |
AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis. |
T11598 |
IAXO-102 |
IAXO-102 also prevents experimental abdominal aortic aneurysm development. IAXO-102 is a TLR4 antagonist which negatively regulates TLR4 signalling. It inhibi...
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T13167 |
TLR7/8 agonist 3 |
TLR7/8 agonist 3 is a potent agonist of TLR7 and TLR8. |
T13168 |
TLR7 agonist 1 |
TLR7 agonist 1 is a potent, selective and oral TLR7 agonist with an IC50 of 90 nM. |
T13182 |
Toll-like receptor modulator |
Toll-like receptor modulator is a TLR7/8 modulator, which modulates immune function. |
T10833 |
CL264 |
CL264, a specific agonist of TLR7, is used for innate immune signals research. |
T15751 |
LHC-165 |
LHC-165 is an agonist of TLR7. It also has the potential to treat solid tumors. |
T15785 |
LPA1 antagonist 1 |
LPA1 antagonist 1 is a highly selective Lysophosphatidic Acid receptor-1 (LPA1) antagonist (IC50: 25 nM). |
T16136 |
MRS-1706 |
MRS-1706 has Ki values of 1.39, 112, 157, and 230 nM for human A2B, A2A, A1, and A3 receptors respectively. MRS-1706 is an effective and selective adenosine A2B...
|
T16506 |
PF-4878691 |
PF-4878691 is an effective and selective Toll-like receptor 7 agonists modelled. It is used to dissociate its antiviral and inflammatory activities. |
T16870 |
Selgantolimod |
Selgantolimod is an effective and selective toll-like receptor 8 agonists for the treatment of the hepatitis B virus and human immunodeficiency virus infection. |
TJS1779 |
Protosappanin A |
Protosappanin A has anti-oxidative/nitrative activities on brain immune and neuroinflammation through regulation of CD14/TLR4-dependent IKK/IκB/NF-κB infl...
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TN3587 |
Capillarisin |
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cel...
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TN4171 |
Grossamide |
Grossamide possesses potential anti-inflammatory effects, it also has potential anti-neuroinflammatory effects against lipopolysaccharide (LPS)-induced inflamma...
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TN5138 |
Teuclatriol |
Teuclatriol was found to be one of the compounds responsible for the immunoinhibitory effect of Salvia mirzayanii, by inhibiting NF-κB signaling at doses of ...
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T8689 |
CHLOROQUINE |
Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria an...
|
TP1067 |
Pam3CSK4 TFA |
Pam3CSK4 TFA is an agonist of toll-like receptor 1/2 (TLR1/2) (EC50 of 0.47 ng/mL for human TLR1/2). |