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CU-CPD107

Catalog No. T35349Cas No. 2573912-32-8
Alias CU-CPD107

CU-CPD107 is a selective agonist of toll-like receptor 8 (TLR8) and also shows activation activity against ssRNA ligands. CU-CPD107 acts as an inhibitor of TLR8 signaling in the presence of R848 (IC50=13.7 μM). CU-CPD107 exhibited coagonist activity in the presence of ssRNA, while CU-CPD107 alone could not affect TLR8 signal transduction.

CU-CPD107

CU-CPD107

Purity: 98.86%
Catalog No. T35349Alias CU-CPD107Cas No. 2573912-32-8
CU-CPD107 is a selective agonist of toll-like receptor 8 (TLR8) and also shows activation activity against ssRNA ligands. CU-CPD107 acts as an inhibitor of TLR8 signaling in the presence of R848 (IC50=13.7 μM). CU-CPD107 exhibited coagonist activity in the presence of ssRNA, while CU-CPD107 alone could not affect TLR8 signal transduction.
Pack SizePriceAvailabilityQuantity
1 mg$60In Stock
5 mg$137In Stock
10 mg$217In Stock
25 mg$397In Stock
50 mg$565In Stock
100 mg$793In Stock
200 mg$1,080In Stock
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Purity:98.86%
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Product Introduction

Bioactivity
Description
CU-CPD107 is a selective agonist of toll-like receptor 8 (TLR8) and also shows activation activity against ssRNA ligands. CU-CPD107 acts as an inhibitor of TLR8 signaling in the presence of R848 (IC50=13.7 μM). CU-CPD107 exhibited coagonist activity in the presence of ssRNA, while CU-CPD107 alone could not affect TLR8 signal transduction.
Targets&IC50
TLR8 (HEK-Blue hTLR8 cells):13.7 μM
In vitro
CU-CPD107 behaved an agonist in the presence of ssRNA in HEK-Blue hTLR8 cells, resulting in a fivefold activation at 100 μΜ by SEAP assay relative to the control. Crucially, CU-CPD107 displayed no agonistic potential in the absence of ssRNA[1].
AliasCU-CPD107
Chemical Properties
Molecular Weight400.25
FormulaC16H21IN2O2
Cas No.2573912-32-8
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 1.8 mg/mL (4.5 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4984 mL12.4922 mL24.9844 mL124.9219 mL

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