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CU-CPD107 is a selective agonist of toll-like receptor 8 (TLR8) and also shows activation activity against ssRNA ligands. CU-CPD107 acts as an inhibitor of TLR8 signaling in the presence of R848 (IC50=13.7 μM). CU-CPD107 exhibited coagonist activity in the presence of ssRNA, while CU-CPD107 alone could not affect TLR8 signal transduction.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $60 | In Stock | |
5 mg | $137 | In Stock | |
10 mg | $217 | In Stock | |
25 mg | $397 | In Stock | |
50 mg | $565 | In Stock | |
100 mg | $793 | In Stock | |
200 mg | $1,080 | In Stock |
Description | CU-CPD107 is a selective agonist of toll-like receptor 8 (TLR8) and also shows activation activity against ssRNA ligands. CU-CPD107 acts as an inhibitor of TLR8 signaling in the presence of R848 (IC50=13.7 μM). CU-CPD107 exhibited coagonist activity in the presence of ssRNA, while CU-CPD107 alone could not affect TLR8 signal transduction. |
Targets&IC50 | TLR8 (HEK-Blue hTLR8 cells):13.7 μM |
In vitro | CU-CPD107 behaved an agonist in the presence of ssRNA in HEK-Blue hTLR8 cells, resulting in a fivefold activation at 100 μΜ by SEAP assay relative to the control. Crucially, CU-CPD107 displayed no agonistic potential in the absence of ssRNA[1]. |
Alias | CU-CPD107 |
Molecular Weight | 400.25 |
Formula | C16H21IN2O2 |
Cas No. | 2573912-32-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
Solubility Information | DMSO: 1.8 mg/mL (4.5 mM) | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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