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CU-CPD107

Catalog No. T35349 CAS 2573912-32-8

Synonyms: CU-CPD107

CU-CPD107 is a selective agonist of toll-like receptor 8 (TLR8) and also shows activation activity against ssRNA ligands. CU-CPD107 acts as an inhibitor of TLR8 signaling in the presence of R848 (IC50=13.7 μM). CU-CPD107 exhibited coagonist activity in the presence of ssRNA, while CU-CPD107 alone could not affect TLR8 signal transduction.

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CU-CPD107, CAS 2573912-32-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 64.00
5 mg	In stock	$ 137.00
10 mg	In stock	$ 217.00
25 mg	In stock	$ 398.00
50 mg	In stock	$ 565.00
100 mg	In stock	$ 793.00

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Purity: 98.86%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CU-CPD107 is a selective agonist of toll-like receptor 8 (TLR8) and also shows activation activity against ssRNA ligands. CU-CPD107 acts as an inhibitor of TLR8 signaling in the presence of R848 (IC50=13.7 μM). CU-CPD107 exhibited coagonist activity in the presence of ssRNA, while CU-CPD107 alone could not affect TLR8 signal transduction.
Targets&IC50	TLR8 (HEK-Blue hTLR8 cells):13.7 μM
In vitro	CU-CPD107 behaved an agonist in the presence of ssRNA in HEK-Blue hTLR8 cells, resulting in a fivefold activation at 100 μΜ by SEAP assay relative to the control. Crucially, CU-CPD107 displayed no agonistic potential in the absence of ssRNA[1].

Synonyms	CU-CPD107
Molecular Weight	400.25
Formula	C16H21IN2O2
CAS No.	2573912-32-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 1.8 mg/mL (4.5 mM)

References and Literature

1. Yang Y, et al. Tetrasubstituted imidazoles as incognito Toll-like receptor 8 a(nta)gonists. Nat Commun. 2021 Jul 16;12(1):4351.

Related compound libraries

This product is contained In the following compound libraries：

Bioactive Compound Library Bioactive Compounds Library Max

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CU-CPD107 2573912-32-8 Immunology/Inflammation TLR CU-CPD-107 CUCPD107 CU CPD107 CU-CPD 107 inhibitor inhibit

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