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AZD8848
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Catalog No. T10437Cas No. 866269-28-5
AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
AZD8848
😃Good
Catalog No. T10437Cas No. 866269-28-5
AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,620 | 6-8 weeks | |
| 50 mg | $2,110 | 6-8 weeks | |
| 100 mg | $3,100 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | AZD8848 is a selective antedrug agonist of toll-like receptor 7 (TLR7). It is developed for the research of asthma and allergic rhinitis. |
| In vitro | AZD8848 is able to inhibit Th2 responses in vitro. AZD8848 shows good activity against TLR7, with cellular pEC50s of 7.0 and 6.6 for human TLR7 and rat TLR7, respectively. AZD8848 has no activity against human TLR8 or against any of the other human TLRs. AZD8848 has an EC50 of 4 nM in the induction of IFNα from human PBMCs and an IC50 of 0.2-1.0 nM for the inhibition of IL-5, irrespective of whether the T cells have been polyclonally stimulated with PHA or via antigen presentation. |
| In vivo | AZD8848 (0.3 mg/kg; Intratracheal) suppresses the ovalbumin (OVA) challenge in the rat allergy model. AZD8848 (0.1-1 mg/kg; intratracheal) has good pharmacokinetics in the Brown Norway rat. |
| Molecular Weight | 569.7 |
| Formula | C29H43N7O5 |
| Cas No. | 866269-28-5 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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