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CU-CPT-8m
🥰Excellent
Catalog No. T7347Cas No. 125079-83-6
Alias TLR8-specific antagonist
CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
CU-CPT-8m
🥰Excellent
Purity: 98.97%
Catalog No. T7347Alias TLR8-specific antagonistCas No. 125079-83-6
CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM)
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $48 | In Stock | |
| 2 mg | $68 | In Stock | |
| 5 mg | $103 | In Stock | |
| 10 mg | $169 | In Stock | |
| 25 mg | $309 | In Stock | |
| 50 mg | $567 | In Stock | |
| 100 mg | $813 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $108 | In Stock |
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CitedChloroquine
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CitedResiquimod Cited
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TLR3-IN-1
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CU-CPD107
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CU-CPD107 is a selective agonist of toll-like receptor 8 (TLR8) and also shows activation activity against ssRNA ligands. CU-CPD107 acts as an inhibitor of TLR8 signaling in the presence of R848 (IC50=13.7 μM). CU-CPD107 exhibited coagonist activity in the presence of ssRNA, while CU-CPD107 alone could not affect TLR8 signal transduction.
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Purity:98.97%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CU-CPT-8m (TLR8-specific antagonist) is an toll-like receptor 8 (TLR8) antagonist (IC50 : 67 nM) |
| Targets&IC50 | TLR8:67 nM |
| In vivo | CU-CPT8m decreases TNF-α and IL-8 levels in synovial cells derived from patients with osteoarthritis and TNF-α levels in PBMCs derived from patients with rheumatoid arthritis. |
| Alias | TLR8-specific antagonist |
| Molecular Weight | 252.27 |
| Formula | C14H12N4O |
| Cas No. | 125079-83-6 |
| Smiles | Cc1cccc(c1)-c1ccnc2c(cnn12)C(N)=O |
| Relative Density. | 1.35 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 30 mg/mL (118.92 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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