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L6H21
🥰Excellent
Catalog No. T69626Cas No. 24533-47-9
Alias L6H-21
L6H21 is an MD-2 inhibitor that can be used to study cognitive impairment and brain damage.
L6H21
🥰Excellent
Catalog No. T69626Alias L6H-21Cas No. 24533-47-9
L6H21 is an MD-2 inhibitor that can be used to study cognitive impairment and brain damage.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $30 | In Stock | |
| 5 mg | $64 | In Stock | |
| 10 mg | $108 | In Stock | |
| 25 mg | $239 | In Stock | |
| 50 mg | $388 | In Stock | |
| 100 mg | $629 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | L6H21 is an MD-2 inhibitor that can be used to study cognitive impairment and brain damage. |
| In vitro | The cells were exposed to ethanol (EtOH; 100 mmol/l) for 48 hours prior to the treatment with LPS at 500 ng/ml for 6 hours. L6H21 was administered (10 or 20 μmol/l) 2 hours before EtOH treatment. L6H21 protects against oxidative stress and apoptosis induced by EtOH and/or LPS in RAW264.7 cells. [1] |
| In vivo | A group of mice was treated with L6H21 via oral gavage at a dose of 10 mg/kg/d on the same day as the start of alcohol feeding. L6H21 treatment significantly decreased inflammation in liver tissue induced by EtOH + LPS. LPS aggravated EtOH-induced hepatic steatosis and liver injury, which was improved with L6H21 pretreatment. L6H21 treatment plays an important role in the inhibition of EtOH + LPS-induced inflammasome activation in the liver. [1] |
| Alias | L6H-21 |
| Molecular Weight | 298.33 |
| Formula | C18H18O4 |
| Cas No. | 24533-47-9 |
| Smiles | O(C)C1=C(/C=C/C(=O)C2=CC=C(OC)C=C2)C=CC=C1OC |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (268.15 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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