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Desethyl chloroquine diphosphate
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Catalog No. T11001LCas No. 247912-76-1
Desethyl chloroquine diphosphate, the active metabolite of Desethylchloroquine, is a cross-placental and orally available inhibitor of toll-like receptors (TLRs) with antiplasmodial activity and inhibition of autophagy.
Desethyl chloroquine diphosphate
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Purity: 99.72%
Catalog No. T11001LCas No. 247912-76-1
Desethyl chloroquine diphosphate, the active metabolite of Desethylchloroquine, is a cross-placental and orally available inhibitor of toll-like receptors (TLRs) with antiplasmodial activity and inhibition of autophagy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $1,139 | In Stock | |
| 5 mg | $1,819 | 7-10 days | |
| 10 mg | $2,728 | 7-10 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Desethyl chloroquine diphosphate, the active metabolite of Desethylchloroquine, is a cross-placental and orally available inhibitor of toll-like receptors (TLRs) with antiplasmodial activity and inhibition of autophagy. |
| In vivo | In the study, amochloroquine was administered by intraperitoneal injection to wild-type mice and Huntington's chorea mice. Levels of amochloroquine and its metabolites were compared in blood, brain and muscle tissue using LC-MS/MS (liquid chromatography-mass spectrometry) techniques. Despite the low concentrations of amochloroquine (5-15 μM), amochloroquine was more stable in the brain than in blood and muscle from 4 to 24 hours after administration. At the same time, Desethyl chloroquine (the active metabolite of amochloroquine) concentrations in blood and muscle decreased after 24 hours, while concentrations in the brain were lower and increased slightly during this period. Desethyl chloroquine diphosphate is a salt form of Desethyl chloroquine. [2] |
| Molecular Weight | 487.81 |
| Formula | C16H28ClN3O8P2 |
| Cas No. | 247912-76-1 |
| Smiles | O=P(O)(O)O.ClC1=CC2=NC=CC(NC(CCCNCC)C)=C2C=C1.O=P(O)(O)O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 1 mg/mL (2.05 mM), Sonication is recommended. H2O: 10 mg/mL (20.5 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO/H2O
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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