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DSR-6434
Catalog No. T11108Cas No. 1059070-10-8
DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.
DSR-6434
Catalog No. T11108Cas No. 1059070-10-8
DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $58 | In Stock | |
| 10 mg | $105 | In Stock | |
| 25 mg | Inquiry | In Stock | |
| 1 mL x 10 mM (in DMSO) | $58 | In Stock |
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Purity:99.12%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | DSR-6434 is a selective agonist of TLR7 with antitumor effect. DSR-6434 exhibits EC50s of 7.2 nM and 4.6 nM for human and mouse. |
| Targets&IC50 | TLR7:4.6 nM (EC50, Mice), TLR7:7.2 nM (EC50, Human) |
| In vitro | To evaluate the specificity of DSR-6434 for TLR7, a NF-κB-driven reporter assay was conducted in HEK293 cells engineered to express hTLR7, TLR8, or TLR9. This assay determines specificity through NF-κB activation upon successful receptor binding. Results demonstrate that DSR-6434 selectively stimulates reporter gene activity in cells expressing hTLR7, but not in those expressing the structurally similar hTLR8 or hTLR9[1]. |
| In vivo | In B6C3F1 mice, DSR-6434 (0.1-1 mg/kg; i.v.) significantly suppresses lung metastasis[1]. |
| Molecular Weight | 400.48 |
| Formula | C19H28N8O2 |
| Cas No. | 1059070-10-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 225 mg/mL (561.8 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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