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Isofraxidin

Isofraxidin
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Purity:99.7%
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Isofraxidin

Catalog No. T5S0045Cas No. 486-21-5
1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the protective effect of Isofraxidin seems to result from the inhibition of COX-2 protein expression in the lung, which regulates the production of PGE2. 3. Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2.
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Pack SizePriceAvailabilityQuantity
5 mg$40In Stock
10 mg$64In Stock
25 mg$118In Stock
50 mg$176In Stock
100 mg$262In Stock
1 mL x 10 mM (in DMSO)$53In Stock
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Product Introduction

Bioactivity
Description
1. Isofraxidin (Phytodolor) protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. 2. Isofraxidin has a protective effect against LPS-induced ALI, and the protective effect of Isofraxidin seems to result from the inhibition of COX-2 protein expression in the lung, which regulates the production of PGE2. 3. Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2.
Alias6,8-Dimethoxyumbelliferone, Phytodolor
Chemical Properties
Molecular Weight222.19
FormulaC11H10O5
Cas No.486-21-5
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year
Solubility Information
DMSO: 40 mg/mL(180 mM)
Chloroform, Dichloromethane, Ethyl Acetate, Acetone, etc.: Soluble
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.5007 mL22.5033 mL45.0065 mL225.0326 mL
5 mM0.9001 mL4.5007 mL9.0013 mL45.0065 mL
10 mM0.4501 mL2.2503 mL4.5007 mL22.5033 mL
20 mM0.2250 mL1.1252 mL2.2503 mL11.2516 mL
50 mM0.0900 mL0.4501 mL0.9001 mL4.5007 mL
100 mM0.0450 mL0.2250 mL0.4501 mL2.2503 mL

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