Shopping Cart
- Remove All
- Your shopping cart is currently empty
Loxoribine (RWJ 21757) is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | 29 € | In Stock | |
10 mg | 49 € | In Stock | |
25 mg | 79 € | In Stock | |
50 mg | 116 € | In Stock | |
100 mg | 172 € | In Stock | |
1 mL x 10 mM (in DMSO) | 33 € | In Stock |
Description | Loxoribine (RWJ 21757) is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities. |
In vitro | Loxoribine selectively activates innate immune system cells through the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway[1], leading to the maturation of human monocyte-derived dendritic cells (DCs) and enhancing their Th-1- and Th-17-polarizing capability[2]. Additionally, loxoribine (250 μM; 48 hours) promotes MoDCs maturation, evident from the increased expression of CD80, CD83, CD40, CD54, and CCR7[2]. |
In vivo | In vivo, Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells[3]. |
Alias | RWJ 21757, 7-Allyl-8-oxoguanosine |
Molecular Weight | 339.3 |
Formula | C13H17N5O6 |
Cas No. | 121288-39-9 |
Smiles | Nc1nc(=O)c2n(CC=C)c(=O)n(C3OC(CO)C(O)C3O)c2[nH]1 |
Relative Density. | 1.92 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 27.5 mg/mL (81.05 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.