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Loxoribine

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Purity:99.73%

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COA HNMR HPLC

Loxoribine

Catalog No. T15777Cas No. 121288-39-9

Loxoribine (RWJ 21757) is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.

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Pack Size	Price	Availability
5 mg	$31	In Stock
10 mg	$52	In Stock
25 mg	$84	In Stock
50 mg	$123	In Stock
100 mg	$182	In Stock
1 mL x 10 mM (in DMSO)	$35	In Stock

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Product Introduction

Bioactivity

Description	Loxoribine (RWJ 21757) is a guanosine analog. Loxoribine is an orally bioavailable and selective Toll-like receptor (TLR) 7 agonist. It has anti-viral and anti-tumor activities.Loxoribine is a potent new immunostimulant with a relatively broad spectrum of immunobiological activities.
In vitro	Loxoribine selectively activates innate immune system cells through the Toll-like receptor (TLR) 7/MyD88-dependent signaling pathway[1], leading to the maturation of human monocyte-derived dendritic cells (DCs) and enhancing their Th-1- and Th-17-polarizing capability[2]. Additionally, loxoribine (250 μM; 48 hours) promotes MoDCs maturation, evident from the increased expression of CD80, CD83, CD40, CD54, and CCR7[2].
In vivo	In vivo, Loxoribine (2 mg; s.c.or i.v.) activates murine natural killer (NK) cells[3].
Alias	RWJ 21757, 7-Allyl-8-oxoguanosine

Chemical Properties

Molecular Weight	339.3
Formula	C13H17N5O6
Cas No.	121288-39-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 27.5 mg/mL (81.05 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9472 mL	14.7362 mL	29.4724 mL	147.3622 mL
5 mM	0.5894 mL	2.9472 mL	5.8945 mL	29.4724 mL
10 mM	0.2947 mL	1.4736 mL	2.9472 mL	14.7362 mL
20 mM	0.1474 mL	0.7368 mL	1.4736 mL	7.3681 mL
50 mM	0.0589 mL	0.2947 mL	0.5894 mL	2.9472 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

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