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ODN 1668
🥰Excellent
Catalog No. T74903Cas No. 1186063-66-0
Alias ODN1668
ODN 1668 is an immunostimulatory class B CpG oligodeoxynucleotide (ODN) containing an intact thio backbone of one or more CpG dinucleotides, which is primarily used as an agonist for Toll-like receptor 9 (TLR9), and also upregulates the level of IgM and induces an antimicrobial immune response via a CaTLR9-dependent pathway.
ODN 1668
ODN 1668
🥰Excellent
Catalog No. T74903Alias ODN1668Cas No. 1186063-66-0
ODN 1668 is an immunostimulatory class B CpG oligodeoxynucleotide (ODN) containing an intact thio backbone of one or more CpG dinucleotides, which is primarily used as an agonist for Toll-like receptor 9 (TLR9), and also upregulates the level of IgM and induces an antimicrobial immune response via a CaTLR9-dependent pathway.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $143 | In Stock | |
| 5 mg | $330 | In Stock | |
| 10 mg | $528 | In Stock | |
| 25 mg | $950 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
| Description | ODN 1668 is an immunostimulatory class B CpG oligodeoxynucleotide (ODN) containing an intact thio backbone of one or more CpG dinucleotides, which is primarily used as an agonist for Toll-like receptor 9 (TLR9), and also upregulates the level of IgM and induces an antimicrobial immune response via a CaTLR9-dependent pathway. |
| In vitro | Treatment of mouse bone marrow-derived macrophages with ODN 1668 (6-60 µg/mL, 12-72 hours) increased the production of S100A8/A9, IL-6, and β-galactosidase. [1] Treatment of anti-CD3-treated CD8+ T cells with ODN 1668 (0.3-3.0 μM, 4 days) promoted cell growth in a dose-dependent manner. [2] Treatment of head kidney lymphocytes with ODN 1668 (0.25-32 μg/mL, 12 hours) promoted the proliferation of head kidney lymphocytes and enhanced the expression of immune genes. [3] |
| In vivo | Treatment of male Wistar rats (175-200 g) with ODN 1668 (1, 5 mg/kg, intraperitoneal and subcutaneous) induced moderate fever and anorexia, and induced a significant increase in IL-6.[4] |
| Alias | ODN1668 |
| Molecular Weight | 6364.1 |
| Cas No. | 1186063-66-0 |
Storage & Solubility Information
| Storage | store under nitrogen,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||
| Solubility Information | H2O: 20 mg/mL (3.14 mM), Sonication is recommended. | ||||||||||
Solution Preparation Table | |||||||||||
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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