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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $135 | In Stock | |
5 mg | $289 | In Stock | |
10 mg | $443 | In Stock | |
25 mg | $732 | In Stock | |
50 mg | $987 | In Stock | |
100 mg | $1,390 | In Stock | |
500 mg | $2,790 | In Stock | |
1 mL x 10 mM (in DMSO) | $297 | In Stock |
Description | SM-276001 is a potent selective agonist of TLR7,and is an orally active interferon (IFN) inducer. |
In vitro | SM-276001 (1 nM-10 μM) dose-dependently activates NF-κB through human TLR7 [2]. |
In vivo | Oral administration of 0.1 mg/kg SM-276001 in mice shows potent IFN-inducing activity [1]. Twice weekly oral administration of SM-276001 at a dose of 3 mg/kg significantly reduced disease burden in mice bearing either Renca or CT26 tumors.[2]. |
Molecular Weight | 327.38 |
Formula | C16H21N7O |
Cas No. | 473930-22-2 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (305.46 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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