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3M-011
😃Good
Catalog No. T14035Cas No. 642473-62-9
3M-011, a potent dual toll-like receptor TLR7/8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibits H3N2 influenza viral replication in the nasal cavity and exhibits strong antitumor activity[1][2][3].
3M-011
😃Good
Catalog No. T14035Cas No. 642473-62-9
3M-011, a potent dual toll-like receptor TLR7/8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibits H3N2 influenza viral replication in the nasal cavity and exhibits strong antitumor activity[1][2][3].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,820 | 8-10 weeks | |
| 50 mg | $2,380 | 8-10 weeks | |
| 100 mg | $3,100 | 8-10 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | 3M-011, a potent dual toll-like receptor TLR7/8 agonist and cytokine inducer, serves as a powerful adjuvant to radiotherapy, eliciting significant local and systemic immune responses. Additionally, it effectively inhibits H3N2 influenza viral replication in the nasal cavity and exhibits strong antitumor activity[1][2][3]. |
| In vitro | 3M-011 (0-100 μg/mL; 24 hours; B16-F10 melanoma cells) treatment decreases B16-F10 melanoma cell counts[1]. In humans, 3M-011 activates TLR7 and TLR8, whereas in mice, it activates only TLR7[1]. NF-κB reporter is integrated into HEK-293 cells transfected with human or mouse TLR7 or TLR8, resulting in dose-dependent NF-κB-controlled luciferase activity, except with mouse TLR8. 3M-011 enhances natural killer (NK) cell cytotoxicity[1]. |
| In vivo | The treatment of scid/NOD mice bearing B16-F10 cells with 3M-011 (1 mg/kg; intravenous injection; every other day for six doses; female scid/NOD mice) demonstrates antitumor effects and induces a dose-dependent increase in serum concentrations of TNF-α and IFN-α/β. Additionally, wild-type C57BL/6 mice are subcutaneously injected with varying doses of 3M-011 (0.01 mg/kg, 0.1 mg/kg, 1 mg/kg, or 10 mg/kg)[1]. |
| Molecular Weight | 391.49 |
| Formula | C18H25N5O3S |
| Cas No. | 642473-62-9 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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