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AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $122 | In Stock | |
5 mg | $297 | In Stock | |
10 mg | $492 | In Stock | |
25 mg | $916 | In Stock | |
50 mg | $1,190 | In Stock | |
100 mg | $1,860 | In Stock | |
1 mL x 10 mM (in DMSO) | $296 | In Stock |
Description | AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research. |
Targets&IC50 | TLR7:3.33μM, TLR9:0.04μM |
In vitro | AT791 effectively inhibited DNA stimulation of HEK:TLR9 cells with an IC50 value of 40 nM, respectively, but was significantly less effective in inhibiting LPS endotoxin stimulation of HEK:TLR4 cells or R848 HEK:TLR7 cells. Methods: To confirm whether the interaction of AT791 with DNA was associated with its ability to inhibit DNA-TLR9 interaction in cells, a live cell version of the oligonucleotide bait assay was developed. A non-stimulatory version of the oligonucleotide CpG2216 was created by inverting the stimulatory CpG motif to GpC to generate GpC2216. Results: Stimulatory CpG2216 induced IL-6 production in BMDCs, whereas AT791 (10 mM) inhibited this production. However, when an excess of non-stimulatory GpC2216 was added, IL-6 induction was restored. GpC2216 itself, either alone or in the presence of AT791, does not stimulate IL-6 production.[1] |
In vivo | Short-term induction of serum interleukin-6 by CpG1668 DNA in mice could be effectively inhibited by pretreatment with AT791 (20 mg/kg).[1] |
Alias | AT 791 |
Molecular Weight | 397.51 |
Formula | C23H31N3O3 |
Cas No. | 1219962-49-8 |
Smiles | N1=C(OC=2C=C(OCCCN(C)C)C=CC12)C3=CC=C(OCCCN(C)C)C=C3 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (201.25 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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