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AT791
🥰Excellent
Catalog No. T61882Cas No. 1219962-49-8
Alias AT 791
AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.
AT791
🥰Excellent
Purity: 99.88%
Catalog No. T61882Alias AT 791Cas No. 1219962-49-8
AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $105 | In Stock | |
| 5 mg | $259 | In Stock | |
| 10 mg | $416 | In Stock | |
| 25 mg | $826 | In Stock | |
| 50 mg | $1,190 | In Stock | |
| 100 mg | $1,860 | In Stock | |
| 200 mg | $2,480 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $286 | In Stock |
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Purity:99.88%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research. |
| Targets&IC50 | TLR7:3.33μM, TLR9:0.04μM |
| In vitro | AT791 effectively inhibited DNA stimulation of HEK:TLR9 cells with an IC50 value of 40 nM, respectively, but was significantly less effective in inhibiting LPS endotoxin stimulation of HEK:TLR4 cells or R848 HEK:TLR7 cells. Methods: To confirm whether the interaction of AT791 with DNA was associated with its ability to inhibit DNA-TLR9 interaction in cells, a live cell version of the oligonucleotide bait assay was developed. A non-stimulatory version of the oligonucleotide CpG2216 was created by inverting the stimulatory CpG motif to GpC to generate GpC2216. Results: Stimulatory CpG2216 induced IL-6 production in BMDCs, whereas AT791 (10 mM) inhibited this production. However, when an excess of non-stimulatory GpC2216 was added, IL-6 induction was restored. GpC2216 itself, either alone or in the presence of AT791, does not stimulate IL-6 production.[1] |
| In vivo | Short-term induction of serum interleukin-6 by CpG1668 DNA in mice could be effectively inhibited by pretreatment with AT791 (20 mg/kg).[1] |
| Alias | AT 791 |
| Molecular Weight | 397.51 |
| Formula | C23H31N3O3 |
| Cas No. | 1219962-49-8 |
| Smiles | N1=C(OC=2C=C(OCCCN(C)C)C=CC12)C3=CC=C(OCCCN(C)C)C=C3 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (201.25 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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