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AT791

🥰Excellent
Catalog No. T61882Cas No. 1219962-49-8
Alias AT 791

AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.

AT791

AT791

🥰Excellent
Purity: 99.88%
Catalog No. T61882Alias AT 791Cas No. 1219962-49-8
AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.
Pack SizePriceAvailabilityQuantity
1 mg$122 In Stock
5 mg$297 In Stock
10 mg$492 In Stock
25 mg$916 In Stock
50 mg$1,190 In Stock
100 mg$1,860 In Stock
1 mL x 10 mM (in DMSO)$296 In Stock
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Purity:99.88%
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Product Introduction

Bioactivity
Description
AT791 is an orally available TLR7 and TLR9 inhibitor, suppressing TLR7 and TLR9 signaling, used in autoimmune lupus research.
Targets&IC50
TLR7:3.33μM, TLR9:0.04μM
In vitro
AT791 effectively inhibited DNA stimulation of HEK:TLR9 cells with an IC50 value of 40 nM, respectively, but was significantly less effective in inhibiting LPS endotoxin stimulation of HEK:TLR4 cells or R848 HEK:TLR7 cells.
Methods: To confirm whether the interaction of AT791 with DNA was associated with its ability to inhibit DNA-TLR9 interaction in cells, a live cell version of the oligonucleotide bait assay was developed.
A non-stimulatory version of the oligonucleotide CpG2216 was created by inverting the stimulatory CpG motif to GpC to generate GpC2216.
Results: Stimulatory CpG2216 induced IL-6 production in BMDCs, whereas AT791 (10 mM) inhibited this production. However, when an excess of non-stimulatory GpC2216 was added, IL-6 induction was restored. GpC2216 itself, either alone or in the presence of AT791, does not stimulate IL-6 production.[1]
In vivo
Short-term induction of serum interleukin-6 by CpG1668 DNA in mice could be effectively inhibited by pretreatment with AT791 (20 mg/kg).[1]
AliasAT 791
Chemical Properties
Molecular Weight397.51
FormulaC23H31N3O3
Cas No.1219962-49-8
SmilesN1=C(OC=2C=C(OCCCN(C)C)C=CC12)C3=CC=C(OCCCN(C)C)C=C3
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (201.25 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5157 mL12.5783 mL25.1566 mL125.7830 mL
5 mM0.5031 mL2.5157 mL5.0313 mL25.1566 mL
10 mM0.2516 mL1.2578 mL2.5157 mL12.5783 mL
20 mM0.1258 mL0.6289 mL1.2578 mL6.2891 mL
50 mM0.0503 mL0.2516 mL0.5031 mL2.5157 mL
100 mM0.0252 mL0.1258 mL0.2516 mL1.2578 mL

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