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Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $97 | In Stock | |
5 mg | $197 | 5 days | |
25 mg | $626 | 6-8 weeks | |
50 mg | $814 | 6-8 weeks | |
100 mg | $1,210 | 6-8 weeks | |
1 mL x 10 mM (in DMSO) | $189 | 5 days |
Description | Sparstolonin B, a selective TLR2 and TLR4 antagonist, is an isocoumarin compound isolated from the tubers of Sparganium stoloniferum and Scirpus yagara with anti-HIV, anticancer, antitumour and anti-inflammatory activities, inhibits selective Toll-like receptors, inhibits free fatty acids It inhibits selective Toll-like receptors, inhibits free fatty acid palmitate-induced chondrocyte inflammation and attenuates post-traumatic arthritis in obese mice, and inhibits lipopolysaccharide-induced inflammation in 3T3-L1 adipocytes, which can be used for validation and mammary carcinoma studies. |
In vitro | Sparstolonin B (1-20 μM; 2-4 days) inhibits cell growth and viability of neuroblastoma cells[3].Sparstolonin B inhibits TLR ligand-induced cytokine expression in mouse macrophages. Sparstolonin B inhibits MyD88 recruitment to TLR4 and TLR2[1].Sparstolonin B generates reactive oxygen species (ROS) in neuroblastoma cells. Sparstolonin B reduces expression of N-myc in neuroblastoma cells[3]. Cell Viability Assay[3] Cell Line: SH-SY5Y, IMR-32, NGP, SKNF-1 and SK-N-BE(2) cells |
In vivo | Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-induced inflammation in 5-6-week-old male C57Bl/6 mice (18-20 g body weight)[1]. |
Molecular Weight | 268.22 |
Formula | C15H8O5 |
Cas No. | 1259330-61-4 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 5 mg/mL (18.64 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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