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Kdo2-Lipid A ammonium
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Catalog No. T38635Cas No. 1246298-62-3
Kdo2-Lipid A ammonium (KLA) is a selective and potent TLR4 agonist, a lipopolysaccharide.Kdo2-Lipid A ammonium induces the release of TNF and PGE2.
Kdo2-Lipid A ammonium
😃Good
Catalog No. T38635Cas No. 1246298-62-3
Kdo2-Lipid A ammonium (KLA) is a selective and potent TLR4 agonist, a lipopolysaccharide.Kdo2-Lipid A ammonium induces the release of TNF and PGE2.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $1,245 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Kdo2-Lipid A ammonium (KLA) is a selective and potent TLR4 agonist, a lipopolysaccharide.Kdo2-Lipid A ammonium induces the release of TNF and PGE2. |
| In vitro | Stimulation with Kdo2-Lipid A ammonium (1 µM) induces the release of both TNF and PGE2 from the cell cultures of adult rat spinal astrocytes[1]. |
| In vivo | Upon intrathecal administration, KDO2-Lipid A ammonium activates toll-like receptor 4 (TLR4) in rats[1]. |
| Molecular Weight | 2306.84 |
| Formula | C110H214N6O39P2 |
| Cas No. | 1246298-62-3 |
| Smiles | CCCCCCCCCCCCCC(O[C@H](CCCCCCCCCCC)CC(O[C@@H]1[C@H]([C@@H](O[C@@H]([C@H]1OP([O-])([O-])=O)CO[C@@]2(C[C@H]([C@@H]([C@@](O2)([H])[C@H](O)CO)O)O[C@]3(O[C@]([C@H]([C@@H](C3)O)O)([H])[C@H](O)CO)C(O)=O)C(O)=O)OC[C@@H]4[C@H]([C@@H]([C@H]([C@H](O4)OP([O-])([O-])=O)NC(C[C@H](O)CCCCCCCCCCC)=O)OC(C[C@H](O)CCCCCCCCCCC)=O)O)NC(C[C@@H](CCCCCCCCCCC)OC(CCCCCCCCCCC)=O)=O)=O)=O.[NH4+].[NH4+].[NH4+].[NH4+] |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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