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TLR7/8/9 antagonist 2
Catalog No. T72035Cas No. 2920729-91-3
TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.
TLR7/8/9 antagonist 2
Catalog No. T72035Cas No. 2920729-91-3
TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis.
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Product Introduction
Bioactivity
Chemical Properties
| Description | TLR7/8/9 antagonist 2 is an orally active and highly bioavailable vTLR7/8/9 antagonist. It inhibits HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50s of 0.011 μM, 0.029 μM, and 0.052 μM, respectively. TLR7/8/9 antagonist 2 can be used to study auto-inflammatory diseases such as systemic lupus erythematosus or lupus nephritis. |
| Targets&IC50 | HEK/hTLR9:0.052 μM, HEK/hTLR7:0.011 μM, HEK/hTLR8:0.029 μM |
| In vitro | TLR7/8/9 antagonist 2 exhibited inhibitory activity against HEK/hTLR7, HEK/hTLR8, and HEK/hTLR9 with IC50 values of 0.011 μM, 0.029 μM, and 0,052 μM, respectively.[1] TLR7/8/9 antagonist 2 showed inhibitory activity against hPBMC/TLR9 with an IC50 value of 420 nM.[1] |
| In vivo | TLR7/8/9 antagonist 2 has a high in vivo bioavailability.[1] |
| Molecular Weight | 405.54 |
| Formula | C23H31N7 |
| Cas No. | 2920729-91-3 |
Storage & Solubility Information
| Storage | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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