Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PHT-427 (CS-0223) is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 mg | In stock | $ 39.00 | |
25 mg | In stock | $ 79.00 | |
50 mg | In stock | $ 155.00 | |
100 mg | In stock | $ 263.00 | |
200 mg | In stock | $ 452.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 43.00 |
Description | PHT-427 (CS-0223) is a dual Akt (Ki: 2.7 μM) and PDPK1 (Ki: 5.2 μM) inhibitor (high-affinity binding for the PH domains of Akt and PDPK1). |
Targets&IC50 | PDK1:5.2 μM(Ki), Akt:2.7 μM(Ki) |
Kinase Assay | Surface plasmon resonance (SPR) spectroscopy binding assays: All interaction analyses are performed with a Biacore 2000, Biacore 2000 Control Software v3.2, and BIAevaluation v4.1 analysis software. The PH domain GST-fusion proteins (Akt1, IRS1, and PDK1) are immobilized on a CM5 Sensorchip using Biacore's Amine Coupling Kit to a level of 10,000 Response units (RUs). Small molecule analytes at concentrations ranging from 0.1 to 10 × the predicted KD are injected at a high flow rate (30μL/min). DMSO concentrations in all samples and running buffer are 1% (v/v) or less. |
Synonyms | PHT 427, CS-0223 |
Molecular Weight | 409.61 |
Formula | C20H31N3O2S2 |
CAS No. | 1191951-57-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 41 mg/mL (100 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
PHT-427 1191951-57-1 Apoptosis Cytoskeletal Signaling PI3K/Akt/mTOR signaling Akt PDK Inhibitor PKB CS 0223 CS0223 PHT 427 inhibit CS-0223 PHT427 Protein kinase B inhibitor