Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively)
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 32.00 | |
5 mg | In stock | $ 67.00 | |
10 mg | In stock | $ 87.00 | |
25 mg | In stock | $ 151.00 | |
50 mg | In stock | $ 226.00 | |
100 mg | In stock | $ 339.00 | |
200 mg | In stock | $ 512.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 74.00 |
Description | Purvalanol B (NG 95) is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively) |
Targets&IC50 | CDK5-p35:6 nM , CDK2-CyclinE:9 nM , CDK2-CyclinA:6 nM , CDK2-CyclinB:6 nM |
In vivo | Purvalanol B application decreases the ability of late-stage P.falciparum trophozoites to form multinucleated schizonts and up-regulates proteasome subunits and proteins that contribute to redox homeostasis, which may indicate an increase in oxidative stress as a result of inhibitor application[1]. |
Animal Research | A SYBR Green I parasite growth assay was used to measure the IC50 of Purvalanol B with P. falciparum (strain W2). Purvalanol B or DMSO control were applied to synchronized parasites 36 hours post invasion and parasites were incubated for 12 hours. Giemsa-stained blood smears were used to determine the effect of Purvalanol B on parasite growth, global quantitative proteomic analysis was used to examine differences in protein expression between Purvalanol B-treated and control parasites and results were confirmed by qPCR[1]. |
Synonyms | NG 95 |
Molecular Weight | 432.9 |
Formula | C20H25ClN6O3 |
CAS No. | 212844-54-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 40 mg/mL (92.40 mM)
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Purvalanol B 212844-54-7 Cell Cycle/Checkpoint Microbiology/Virology Parasite CDK cdc2 NG 95 inhibit cyclin CDK2 NG95 CDK5 NG-95 P. falciparum ATP Cyclin dependent kinase Inhibitor p35 inhibitor