CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.

Cat No.	product name
T21966	MeBIO	MeBIO 是一种芳烃受体激动剂，对 GSK-3 和 CDK1/CyclinB 的 IC50 分别为 44 和 55 μM。 MeBIO 不影响 GSK-3β。
T36694	XY028-140	XY028-140 是一种特异性 CDK4/CDK6 降解，抑制 CDK4/6 在癌细胞中的表达和活性。 XY028-140 是一种 PROTAC，由 Cereblon 配体和 CDK 配体相连接。
T8325	SR-4835	SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (TNB...
T8866	GW779439X	GW779439X is an inhibitor of CDK.
T6563	LDC000067	LDC000067 is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM.
T9083	TC11	TC11 is a potent inhibitor of tumor cell proliferation and an inducer of apoptosis via activation of caspase-3, 8 and 9.
T4135	OTS964 hydrochloride	OTS964 is a potent and selective TOPK inhibitor with potential anticancer activity.
T2029	Bohemine	Bohemine is a cyclin-dependent kinase inhibitor.
T14072	A-443654	A-443654 is a pan-Akt inhibitor. It has equal potency against Akt1, Akt2, or Akt3 within cells (Ki=160 pM).
T6052	GW 441756	GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM.
T2933	Wogonin	Wogonin is a cell-permeable and orally available flavonoid that displays anti-inflammatory and anticancer properties.
T1947	BS-181	BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9.
T8576	P18IN011	P18IN011 is a novel inhibitor of p18(INK4C).
T2709	TAK-901	TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others....
T4482	CC-671	CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor.
T9636	Dalpiciclib	Dalpiciclib is a highly selective, orally bioavailable, and comparable potency inhibitor of CDK4 and CKD6 with IC50s of 12.4 nM and 9.9 nM, respectively. Dalpici...
T22260	Aminopurvalanol A	Aminopurvalanol A is a competitive, selective and cell-permeable inhibitor of cyclin-dependent kinase (CDK) that potently inhibits Cyclin A/cdk2, Cyclin B/cdk1, ...
T6169	Indirubin	Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 uM and 0.6 uM.
T4051	LDC4297	LDC4297 is a potent and selective CDK7 inhibitor.
T6837	Flavopiridol	Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, 4...
T2463	ML141	ML141 is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM).
T1830	BX795	BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respect...
T3971	CASIN	CASIN is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM).
T2440	IC261	IC261 is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM.
T9446	KB-0742 dihydrochloride	KB-0742 dihydrochloride is a potent, selective and orally inhibitor of CDK9.
T6205	AT7519	AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7.
T6028	PF 477736	PF-477736 is a specifc, effective and ATP-competitive Chk1 inhibitor (Ki: 0.49 nM ) and also inhibits FGFR3, Aurora-A, VEGFR2, Flt3, Fms (CSF1R), Ret and Yes.
TN1651	Furanodiene	Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans.
T1778	AT7519 Hydrochloride	AT7519 hydrochloride is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9.
T2059	Purvalanol A	Purvalanol A is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively.
T6154	SU11274	SU11274(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2.
T8972	FIT-039	FIT-039 is a selective and ATP-competitive, orally active inhibitor of CDK9( IC50 : 5.8 μM;CDK9/cyclin T1). FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μ...
T6049	SNS-032	SNS-032 is a selective inhibitor of CDK2 (IC50: 48 nM ) and is 10- and 20-fold selective over CDK1/CDK4. It is also sensitive to CDK7/9 (IC50: 62 nM/4 nM), and n...
T2113	PHA-793887	PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors.
T16750	Rigosertib	Rigosertib is a selective and non-ATP-competitive inhibitor of PLK1 (IC50: 9 nM). Rigosertib is a multi-kinase inhibitor and a selective anti-cancer agent, which...
T4205	AG-494	AG-494 is an inhibitor of epidermal growth factor receptor kinase.
T1917	GSK 3 Inhibitor IX	BIO is a specific inhibitor of GSK-3.
T1837	BX-912	BX-912 is a specific inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1, IC50: 12 nM). The selectivity of BX-912 is more 10 fold than C-Kit, EGFR, PKA, PKC...
T10898	Samuraciclib hydrochloride	Samuraciclib hydrochloride is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41 nM. The selectivity of Samuraciclib hydrochlor...
TN1068	Tricin	Tricin can inhibit human cytomegalovirus (HCMV) replication by inhibiting CDK9. Tricin inhibits the proliferation and invasion of C6 glioma cells via the upregul...
T3207	Briciclib	Briciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells.
T6057	URMC-099	URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM)...
T10172	5-Iodo-indirubin-3'-monoxime	5-Iodo-indirubin-3'-monoxime is a potent GSK-3β, CDK5/P25 and CDK1/cyclin B inhibitor, competing with ATP for binding to the catalytic site of the kinase (IC50s:...
T12617L	(R)-CR8	(R)-CR8 is a potent and selective CDK inhibitor.
T10659	Ca2+ channel agonist 1	Ca2+ channel agonist 1 is an agonist of N-type Ca2+ channel and an inhibitor of Cdk2 (EC50s: 14.23 μM and 3.34 μM) and is used as a potential treatment for motor...
T2032	WHI-P180	WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
T14918	CDK9-IN-2	CDK9-IN-2 is a special CDK9 inhibitor extracted from patent WO/2012131594A1 (compound CDKI(8)) and has an IC50 of 5 nM and 7 nM in A2058 skin cell line (72 hours...
T14778	BRD6989	BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant C...
T4444	A-674563 HCl (552325-73-2(free base))	A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2 ...
T9734	Benzo[b]thiophene-2-sulfonamide, N-[3-(aminomethyl)phenyl]-5-chloro-3-methyl-	Benzo[b]thiophene-2-sulfonamide, N-[3-(aminomethyl)phenyl]-5-chloro-3-methyl- directly inhibits InhA and does not require activation by the catalase peroxidase K...