T10096 |
(2S,3R)-Voruciclib |
(2S,3R)-Voruciclib is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor. |
T10220 |
Abemaciclib Metabolites M2 |
Abemaciclib Metabolites M2 is a metabolite of abemaciclib, acts as a potent CDK4 and CDK6 inhibitor (IC50s: 1-3 nM) with anti-cancer activity. |
T10382 |
AS2863619 free base |
AS2863619 free base enables the conversion of antigen-specific effector/memory T cells into Foxp3+ regulatory T (Treg) cells. It is a potent, orally active CDK8...
|
T10436 |
AZD4573 |
AZD4573 is an effective and selective CDK9 inhibitor (IC50: <4 nM). It enables transient target engagement for the treatment of hematologic malignancies. |
T10464 |
Atuveciclib |
Atuveciclib (BAY-1143572) is a potent and highly selective, oral PTEFb/CDK9 inhibitor. It inhibits CDK9/CycT1 (IC50: 13 nM). |
T10464L |
Atuveciclib Racemate |
Atuveciclib is a potent and highly selective, oral P-TEFb/CDK9 inhibitor which supresses CDK9/CycT1 with an IC50 of 13 nM. Atuveciclib Racemate (BAY-1143572 Rac...
|
T10465 |
Atuveciclib S-Enantiomer |
Atuveciclib (BAY-1143572) S-enantiomer is a potent and selective CDK9 inhibitor (IC50: 16 nM for CDK9/CycT1). |
T10546 |
bio-THZ1 |
bio-THZ1 is a biotinylated version of THZ1. THZ1 is a selective and irreversibly covalent CDK7 inhibitor (IC50: 3.2 nM). |
T10550 |
Bisindolylmaleimide X hydrochloride |
Bisindolylmaleimide X hydrochloride (BIM-X hydrochloride) is a potent and selective PKC inhibitor. It is also a potent CDK2 antagonist (IC50: 200 nM). |
T10724 |
Cdc7-IN-1 |
Cdc7-IN-1 is a highly selective and ATP competitive inhibitor of Cdc7 kinase (IC50: 0.6 nM at 1 mM ATP). It potently inhibits Cdc7 activity in cancer cells and ...
|
T10735 |
CDK4/6/1 Inhibitor |
CDK4/6/1 Inhibitor is a CDK4/6 inhibitor (IC50s: 3 and 1 nM). |
T10736 |
CDK4/6-IN-2 |
CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor (IC50s: 2.7 and 16 nM) extracted from patent US20180000819A1 (Compound 1). |
T10737 |
CDK4/6-IN-3 |
CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor (Kis: <0.3 nM and 2.2 nM) used for the treatment of glioblastoma. It inhibits CDK1 with a Ki of 110 nM. |
T10738 |
CDK4/6-IN-4 |
CDK4/6-IN-4 is a selective CDK4/6 inhibitor and the active metabolite of Abemaciclib. |
T10739 |
CDK8/19-IN-1 |
CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9). |
T10740 |
CDK8-IN-1 |
CDK8-IN-1 is a selective CDK8 inhibitor (IC50: 3 nM). |
T10741 |
CDK9-IN-1 |
CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection (IC50: 39 nM for CDK9/CycT1). |
T10742 |
CDK9-IN-10 |
CDK9-IN-10 is a potent CDK9 inhibitor and the ligand for the PROTAC CDK9 degrader-2. |
T10743 |
CDK9-IN-11 |
CDK9-IN-11 is a potent CDK9 inhibitor and the ligand for the PROTAC CDK9 degrader-1. |
T10744 |
SEL120-34A |
SEL120-34A is a selective, orally available, and ATP-competitive CDK8 inhibitor (IC50s: 4.4 nM and 10.4 nM for CDK8/CycC and CDK19/CycC) with antitumor activity...
|
T10744L |
SEL120-34A HCl |
SEL120-34A HCl is a selective, orally available and ATP-competitive inhibitor of CDK8(CDK8/CycC and CDK19/CycC with IC50s of 4.4 nM and 10.4 nM , respectively),...
|
T10744L2 |
SEL120-34A monohydrochloride |
SEL120-34A monohydrochloride is an ATP-competitive and selective inhibitor of CDK8(CDK8/CycC and CDK19/CycC complexes with IC50s of 4.4 nM and 10.4 nM, respecti...
|
T10745 |
CDK9-IN-7 |
CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50: 11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD: 148 nM; CDK6/...
|
T10746 |
CDK9-IN-8 |
CDK9-IN-8 is a highly potent and selective CDK9 inhibitor (IC50: 12 nM). |
T10747 |
CDK9-IN-9 |
CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50: 1.8 nM) with anti-cancer activity. It inhibits CDK2 (IC50: 155 nM). |
T10836 |
CLK1-IN-1 |
CLK1-IN-1 is a potent and selective inhibitor of the Cdc2-like kinase 1 (CLK1; IC50: 2 nM). |
T10898 |
Samuraciclib hydrochloride |
Samuraciclib hydrochloride (CT7001 hydrochloride; ICEC0942 hydrochloride) is a potent, selective, ATP competitive and oral active CDK7 inhibitor with IC50 of 41...
|
T11309 |
FMF-04-159-2 |
FMF-04-159-2 inhibits CDK14 and CDK2 with IC50s of 39.6 nM and 256 nM in NanoBRET assay, respectively. FMF-04-159-2 is a covalent CDK14 inhibitor. |
T11345 |
Lerociclib |
Lerociclib (G1T38) is a potent and selective inhibitor of CDK4/6, with IC50s of 2nM, 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively. |
T11345L |
Lerociclib dihydrochloride |
Lerociclib dihydrochloride is a potent and selective inhibitor of CDK4/CDK6, with IC50s of 2 nM and 1 nM for CDK6/CyclinD3 and CDK4/CyclinD1, respectively. |
T11632 |
IIIM-290 |
IIIM-290 is a oral and potent CDK inhibitor with IC50s of 90 and 94 nM for CDK2/A and CDK9/T1. |
T11655 |
Indomethacin-D4 |
Indomethacin-D4 is a deuterium labeled Indomethacin. Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for hum...
|
T11656 |
Indoramin D5 |
Indoramin D5 is a piperidine antiadrenergic agent. Indoramin D5 is deuterium labeled Indoramin. |
T11723 |
JNJ-39758979 dihydrochloride |
JNJ-39758979 dihydrochloride functionally antagonizes histamine-induced cAMP inhibition with a pA2 of 7.9 in transfected cells. JNJ-39758979 dihydrochloride sho...
|
T12355 |
Palbociclib D8 |
Palbociclib D8 is a deuterium labeled Palbociclib. Palbociclib is a selective and orally active inhibitor of CDK4 and CDK6 (IC50s of 11 and 16 nM, respectively)...
|
T12552 |
PROTAC CDK2/9 Degrader-1 |
PROTAC CDK2/9 Degrader-1 is a potent CDK2 and CDK9 dual degrader(DC50 of 62 nM and 33 nM). |
T12617 |
(R)-CR8 trihydrochloride |
(R)-CR8 trihydrochloride is a potent inhibitor CDK1/2/5/7/9. |
T12617L |
(R)-CR8 |
(R)-CR8 is a potent and selective CDK inhibitor. |
T12642L |
Simurosertib |
Simurosertib is a selective and ATP-competitive cell division cycle 7 kinase inhibitor (IC50: <0.3 nM). |
T13044 |
SY-1365 |
SY-1365 is a highly selective covalent CDK7 inhibitor. SY-1365 possesses therapeutic potential in both hematological and solid tumors. |
T13058 |
T025 |
T025 is a highly potent and orally available inhibitor of Cdc2-like kinase (CLK)(Kds of 4.8, 0.096, 6.5, and 0.61 nM for CLK1, CLK2, CLK3, and CLK4, respectivel...
|
T13153 |
THZ1-R |
THZ1-R displays diminished activity for CDK7 inhibition(Kd:142 nM). |
T13202 |
Trilaciclib hydrochloride |
Trilaciclib hydrochloride is an inhibitor of CDK4/6 (IC50s of 1 nM and 4 nM for CDK4 and CDK6, respectively). |
T13202L |
Trilaciclib |
Trilaciclib is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6, respectively). |
T13309 |
Voruciclib hydrochloride |
Voruciclib hydrochloride is an orally active and selective inhibitor of CDK(Ki of 0.626 nM-9.1 nM). |
T13370 |
YM-46303 |
YM-46303 is an antagonist of mAChR |
T13425 |
(1S,3R,5R)-PIM447 dihydrochloride |
(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3). |
T13627 |
CP-10 |
CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells incl...
|
T13696 |
FN-1501-propionic acid |
FN-1501-propionic acid and a CRBN ligand have been used to design PROTAC CDK2/9 degrader . FN-1501-propionic acid is a CDK2/9 ligand for PROTAC. |
T14136 |
AG-024322 |
AG-024322 is a potent ATP-competitive inhibitor of pan-CDK against cell cycle kinases CDK1, CDK2, and CDK4(Ki values in the 1-3 nM range) |
T14367 |
AZ1495 |
AZ1495 is an oral active Interleukin-1 receptor associated kinase 4 (IRAK4) inhibitor(IC50 of 5 nM and 23 nM for IRAK4 and IRAK1, respectively). |
T14778 |
BRD6989 |
BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or ...
|
T14779 |
BRD7389 |
BRD7389 is an inducer of insulin expression in pancreatic α-cells and a specific inhibitor of RSK family kinase (IC50s: 1.5 μM, 2.4 μM, and 1.2 μM for RSK1,...
|
T14901 |
CCT-251921 |
CCT-251921 is a potent, selective, and orally bioavailable CDK8 inhibitor (IC50: 2.3 nM). |
T14914 |
Cdk1/2 Inhibitor III |
Cdk1/2 Inhibitor III is a selective Cdk1/2 inhibitor (IC50: 2.1 μM for CDK1/cyclin B). |
T14915 |
CDK12-IN-E9 |
CDK12-IN-E9 is a potent and selective covalent CDK12 inhibitor and non-covalent CDK9 inhibitor while avoiding ABC transporter-mediated efflux. It has a weak bin...
|
T14916 |
CDK2-IN-4 |
CDK2-IN-4 is a potent and selective CDK2 inhibitor (IC50: 44 nM for CDK2/cyclin A). It shows 2,000-fold selectivity over CDK1/cyclin B (IC50: 86 uM). |
T14918 |
CDK9-IN-2 |
CDK9-IN-2 is a special CDK9 inhibitor extracted from patent WO/2012131594A1 (compound CDKI(8)) and has an IC50 of 5 nM and 7 nM in A2058 skin cell line (72 hour...
|
T14919 |
CDKI-73 |
CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells (LD50: 80 nM) versus normal B cell and normal CD34+ cell (LD50>20 μM). |
T14980 |
CLK-IN-T3 |
CLK-IN-T3 is a potent inhibitor of CDC-like kinase (CLK) (IC50s: 0.67 nM, 15 nM, and 110 nM for CLK1, CLK2, and CLK3 protein kinases) with anti-cancer activity...
|
T14990 |
CDK12-IN-3 |
CDK12-IN-3 is a selective CDK12 inhibitor (IC50: 491 nM in an enzymatic assay). |
T15204 |
EHT 5372 |
EHT 5372 is a strong DYRK’s family kinases of inhibitor (IC50s: 0.22, 0.28 nM for DYRK1A and DYRK1B, respectively). |
T15335 |
FN-1501 |
FN-1501 is a potent FLT3 and CDK inhibitor (IC50s: 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively). FN-...
|
T15730 |
Ribociclib hydrochloride |
Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It is over 1,000-fold less potent against the cyclin B/CDK...
|
T15731 |
Ribociclib succinate hydrate |
Ribociclib succinate hydrate is a highly specific CDK4/6 inhibitor (IC50 values of 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent agains...
|
T15732 |
Ribociclib succinate |
Ribociclib succinate is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It also is over 1,000-fold less potent against the cyclin B/C...
|
T16038 |
Men 10376 |
Men 10376 is a selective antagonist of tachykinin NK-2 receptor. It has a Ki of 4.4 μM for rat small intestine NK-2 receptor. |
T16345 |
NS13001 |
NS13001 is a potent, selective, orally active allosteric positive modulator of SK channels (small conductance calcium-activated potassium channels). The EC50s a...
|
T16363 |
NVP-2 |
NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC5...
|
T16391 |
ON-013100 |
ON-013100 is an antineoplastic drug. It also acts as a mitotic inhibitor that could inhibit Cyclin D1 expression. |
T16784 |
Roniciclib |
Roniciclib is an inhibitor of pan-cyclin dependent kinase (IC50s: 5-25 nM for CDK1, CDK2, CDK3, CDK4, CDK7, and CDK9). |
T17069 |
THAL-SNS-032 |
THAL-SNS-032 is a selective CDK9 degrader PROTAC. |
T17305 |
CDK8-IN-4 |
CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM). |
T1778 |
AT 7519 hydrochloride salt |
AT7519 hydrochloride is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9. |
T1785 |
Palbociclib |
Palbociclib is an orally available cyclin-dependent kinase (CDK) inhibitor with potential antineoplastic activity. Palbociclib selectively inhibits cyclin-depen...
|
T1830 |
BX795 |
BX795 is an effective and selective PDK1 inhibitor (IC50: 6 nM), and its selectivity is 140- and 1600-fold for PDK1 over PKA and PKC in cell-free assays, respec...
|
T1837 |
BX912 |
BX-912 is a specific inhibitor of 3-Phosphoinositide-dependent Kinase-1 (PDK1, IC50: 12 nM). The selectivity of BX-912 is more 10 fold than C-Kit, EGFR, PKA, PK...
|
T1855 |
ZCL 278 |
ZCL278 is a selective Cdc42 GTPase inhibitor. |
T1912 |
DinaciclibHOT |
Dinaciclib is a new-type and effective CDK inhibitor for CDK2/5/1/9 (IC50: 1 nM/1 nM/3 nM/4 nM) with potential antineoplastic activity. |
T1917 |
6-BIO |
BIO is a specific inhibitor of GSK-3. |
T1947 |
BS-181 |
BS-181 is a highly selective CDK7 inhibitor (IC50: 21 nM); >40-fold selective for CDK7 than CDK1/2/4/5/6/9. |
T2028 |
NG-52 |
NG 52 is a cell-permeable, reversible, and ATP-compatible inhibitor of the cell cycle-regulating kinase Cdc28p and the related Pho85p kinase. |
T2029 |
Bohemine |
Bohemine is a cyclin-dependent kinase inhibitor. |
T2032 |
WHI-P180 |
WHI-P180 is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively. |
T2059 |
Purvalanol A |
Purvalanol A is an effective and cell-permeable CDK inhibitor with IC50 of 70/4/35/850 nM for cdk2-cyclin A/B/E, and cdk4-cyclin D1, respectively. |
T2082 |
CDK4-IN-1 |
CDK4 inhibitor is a novel and specific CDK4/Cyclin D1 inhibitor with an IC50 of 10 nM; 1500 and 500 fold than CDK1/Cyclin B (IC50>15 uM) and CDK2/Cyclin A (IC50...
|
T2095 |
RoscovitineHOT |
Roscovitine is a potent inhibitor of Cdk2/cyclin E (IC50: 0.1 μM). It also inhibits Cdk7/cyclin H, Cdk5/p35, and Cdc2/cyclin B (IC50s: 0.49/0.16/0.65 μM). |
T2113 |
PHA-793887 |
PHA-793887 has been used in trials studying the treatment of Advanced/Metastatic Solid Tumors. |
T2118 |
SC-514 |
SC-514 is a selective, orally active, ATP-competitive IKK-2 inhibitor (IC50=11.2±4.7 μM), obstructs NF-κB-dependent gene expression. |
T2153 |
1 nM-PP1 |
1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors. |
T2193 |
2-Chloropyrazine |
2-Chloropyrazine is used in chemical industry. |
T2246 |
LRRK2-IN-1 |
LRRK2-IN-1 is an effective and selective LRRK2 inhibitor. |
T2247 |
KenPaullone |
Kenpaullone, a potent CDK1, CDK2 and CDK5 inhibitor, as new enhancer for iTreg cell differentiation. Kenpaullone promotes iTreg cell differentiation through inc...
|
T2356 |
Ro 3306 |
RO-3306 is a selectivity ATP-competitive CDK1 inhibitor (Ki: 20 nM). The selectivity of RO-3306 for CDK1 is >15-fold higher than a diverse panel of human kinase...
|
T2378 |
RGB-286638 free base |
RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK...
|
T2381 |
Abemaciclib |
LY2835219 is an effective and specific CDK4/6 inhibitor (IC50: 2/10 nM). |
T2440 |
IC261 |
IC261 is a novel inhibitor of CK1, triggers the mitotic checkpoint control. The IC50 of IC261 for CK1 was 16 μM and for Cdk5 is 4.5 mM. |
T2463 |
ML141 |
ML141 is an effective, specific and reversible non-competitive inhibitor of Rho family GTPase cdc42 (IC50: 200 nM). |
T2465 |
PF-562271 |
PF-562271 is an effective ATP-competitive, reversible inhibitor of FAK(IC50=1.5 nM) and Pyk2 kinase(IC50=13 nM). |
T2506 |
AZD5438 |
AZD5438 is an effective inhibitor of CDK, for CDK1(IC50=16 nM),CDK2(IC50=6 nM),CDK9(IC50=20 nM). |
T2517 |
MK-8776 |
CHK1 Inhibitor MK-8776 is an agent targeting cell cycle checkpoint kinase 1 (Chk1) with potential radiosensitization and chemosensitization activities. |
T2615 |
Flavopiridol hydrochloride |
Alvocidib Hydrochloride is a synthetic N-methylpiperidinyl chlorophenyl flavone compound. As an inhibitor of cyclin-dependent kinase, alvocidib induces cell cyc...
|
T2670 |
ML167 |
ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor. |
T2679 |
BMS265246 |
BMS-265246 is a potent and selective CDK1/2 inhibitor. |
T2695 |
TBB |
TBB(NSC 231634) is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2). |
T2709 |
TAK901 |
TAK-901 has been used in trials studying the treatment of Lymphoma, Myelofibrosis, Multiple Myeloma, Myeloid Metaplasia, and Advanced Solid Tumors, among others...
|
T3111 |
abemaciclib mesylate |
LY2835219 is a specific and effective inhibitor of CDK4(IC50=2 nM) and CDK6(IC50=10 nM). |
T3166 |
VX-11e |
VX-11e is a potent, selective, and orally bioavailable ERK(Extracellular Signal-Regulated Kinase) inhibitor; antitumor agent. |
T3186 |
NU2058 |
NU2058 is a guanine-based CDK inhibitor, also inhibits DNA topoisomerase II ATPase activity. |
T3195 |
CVT-313 |
CVT-313(NG-26) is a potent, selective, reversible, and ATP-competitive inhibitor. |
T3207 |
Briciclib |
Briciclib is a small molecule that suppresses cyclin D1 accumulation in Y cells. |
T3352 |
XL413 |
XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. XL-413 binds to and inhibits the ...
|
T3589 |
NSC23005 Sodium |
NSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models. |
T3590 |
NSC23005 |
NSC23005 sodium is a p18INK inhibitor with potently promoted hematopoietic stem cell (HSC) expansion (ED50: 5.21 nM). |
T3664 |
THZ1 |
THZ1 is a novel selective and potent covalent CDK7 inhibitor. |
T3700 |
SCH900776 S-isomer |
SCH900776 (S-isomer) is an effective, specific and orally bioavailable inhibitor of checkpoint kinase Chk1 (IC50: 3 nM). It also inhibitors Chk2 (IC50: 1500 nM)...
|
T3971 |
CASIN |
CASIN is a specific inhibitor of GTPase Cdc42 (IC50: 2 uM). |
T4227 |
SB1317 hydrochloride (1204918-72-8(free base)) |
SB1317 is an effective inhibitor of CDK2/JAK2/FLT3 (IC50: 13/73/56 nM). |
T4293 |
THZ531 |
THZ531 is a covalent inhibitor of both CDK12(IC50=158 nM) and CDK13(IC50=69 nM). |
T4321 |
Indisulam |
Indisulam is a carbonic anhydrase inibitor and Antitumor CDK inhibitor. Indisulam targets the G1 phase of the cell cycle by depleting cyclin E. inducing p53 and...
|
T4417 |
LDC-4297 HCl (1453834-21-3(free base)) |
LDC4297 is a potent and selective CDK7 inhibitor with an IC50 of 0.13 nM. |
T4444 |
A-674563 HCl (552325-73-2(free base)) |
A-674563 is an orally available, ATP-competitive, and reversible inhibitor of Akt (Ki: 11 nM for Akt1) [1]. It exhibits inhibitory activity against PKA and Cdk2...
|
T4482 |
CC-671 |
CC-671 is a dual TTK protein kinase (IC50: 0.005 μM) /CLK2 (IC50: 0.006 μM) inhibitor. |
T5200 |
Indirubin-3'-monoxime |
Indirubin-3’-oxime is a potent inhibitor of GSK3β (IC50: 22 nM) and also inhibits CDKs ( (IC50s: 100/180/250 nM for Cdk5/p35, Cdk1/cyclin B, Cdk2/cyclin E). |
T5358 |
Longdaysin |
Longdaysin is an inhibitor of CK1α and CK1δ (IC50s: 5.6/8.8 μM). It also can inhibit ERK2 (IC50: 52 μM). |
T5395 |
BSJ-03-123 |
BSJ-03-123 is a potent and novel CDK6-selective small-molecule degrader (PROTAC). |
T5405 |
BI-1347 |
BI-1347 is a potent, selective inhibitor of CDK8/cyclinC (IC50: 1 nM). It shows tumor growth inhibition in an in vivo xenograft model. |
T5533 |
MC180295 |
MC180295 is a novel potent, highly selective CDK9 inhibitor (IC50: 5 nM), displays >22-fold selectivity over other CDKs. |
T5673 |
Senexin A |
Senexin A is an effective and selective CDK8 inhibitor that also inhibits CDK19 with Kd values of 0.83 microns and 0.31 microns, respectively. |
T6049 |
SNS-032 |
SNS-032 is a selective inhibitor of CDK2 (IC50: 48 nM ) and is 10- and 20-fold selective over CDK1/CDK4. It is also sensitive to CDK7/9 (IC50: 62 nM/4 nM), and ...
|
T6052 |
GW 441756 |
GW 441756 is a specific Tropomyosin-related kinase A (TrkA) inhibitor with an IC50 value of 2 nM. |
T6057 |
URMC-099 |
URMC-099 is an orally bioavailable, brain penetrant MLK inhibitor (IC50: 19/42/14/150 nM, for MLK1/MLK2/MLK3/DLK), and also inhibits LRRK2 activity (IC50: 11 nM...
|
T6126 |
JNJ-7706621 |
JNJ-7706621 is a potent aurora kinase inhibitor, and also inhibits CDK1 and CDK2. |
T6139 |
A-674563 |
A-674563 is an Akt1 inhibitor with Ki of 11 nM, modest potent to PKA and >30-fold selective for Akt1 over PKC. |
T6154 |
SU11274 |
SU11274(IC50=10 nM) is a specific Met inhibitor. It shows no significant effects on PGDFRβ, EGFR or Tie2. |
T6162 |
BS-181 HCl |
BS-181 HCl is a highly selective CDK7 inhibitor with IC50 of 21 nM. It is more than 40-fold selective for CDK7 than CDK1, 2, 4, 5, 6, or 9. |
T6167 |
SU9516 |
SU9516 is a potent CDK2 inhibitor, with an IC50 of 22 nM, and also has inhibitory effects on CDK1 and CDK4, with IC50s of 40 nM and 200 nM, respectively. |
T6169 |
Indirubin |
Indirubin is a potent cyclin-dependent kinases and GSK-3β inhibitor with IC50 of about 5 uM and 0.6 uM. |
T6177 |
PF-562271 besylate |
PF-562271 (besylate) is a potent, ATP-competitive, reversible inhibitor of FAK with IC50 of 1.5 nM, ~10-fold less potent for Pyk2 than FAK and >100-fold selecti...
|
T6199 |
Ribociclib |
LEE011 is an orally available, and highly specific CDK4/6 inhibitor (IC50:10/39 nM). |
T6205 |
AT7519 |
AT7519 is a CDK1/2/4/6/9 inhibitor (IC50: 10-210 nM). It is less effective to CDK3 and little active to CDK7. |
T6206 |
PHA-767491 |
PHA-767491 is a potent ATP-competitive dual Cdc7/CDK9 inhibitor with IC50 of 10 nM and 34 nM, respectively. |
T6223 |
U0126-EtOHHOT |
U0126-EtOH is a non-ATP competitive specific inhibitor of MEK1/2 (IC50: 0.07/0.06 μM). |
T6239 |
Palbociclib hydrochlorideHOT |
Palbociclib (PD-0332991) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional protein kinases. |
T6240 |
Palbociclib IsethionateHOT |
Palbociclib (PD-0332991) is a selective inhibitor of CDK4/6 (IC50s: 11/16 nM). It exhibits no inhibition against a panel of 36 additional protein kinases. |
T6255 |
Bromosporine |
Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively. |
T6458 |
CYC116 |
CYC116 is a potent inhibitor of Aurora A/B with Ki of 8.0 nM/9.2 nM, is less potent to VEGFR2 (Ki of 44 nM), with 50-fold greater potency than CDKs, not active ...
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T6563 |
LDC000067 |
LDC000067 is a highly specific and selective CDK9 inhibitor with an IC50 value of 44±10 nM. |
T6612 |
NU6027 |
NU6027 is a potent ATR/CDK inhibitor, inhibits CDK1/2, ATR and DNA-PK with Ki of 2.5 μM/1.3 μM, 0.4 μM and 2.2 μM, enter cells more readily than the 6-amino...
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T6735 |
XL413 hydrochloride |
XL-413 is an orally bioavailable cell division cycle 7 homolog (CDC7) kinase inhibitor with potential antineoplastic activity. CDC7 kinase inhibitor BMS-863233 ...
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T6756 |
AMG 925 |
AMG 925 is a potent and orally bioavailable dual FLT3/CDK4 inhibitor with IC50 of 1 nM and 3 nM, respectively. |
T6786 |
BI-9564 |
BI-9564, a specific cell-permeable BRD9 BD inhibitor. The Kd for BRD9 is 5.9 nM, and IC50 for BET family is > 100 μM. |
T6837 |
Flavopiridol |
Flavopiridol (Alvocidib) competes with ATP to inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 of ~ 40 nM. It is 7.5-fold more selective for CDK1, 2, ...
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T6866 |
K03861 |
K03861 is a type II CDK2 inhibitor with Kd of 50 nM, 18.6 nM, 15.4 nM, and 9.7 nM for CDK2(WT), CDK2(C118L), CDK2(A144C), and CDK2(C118L/A144C), respectlvely. |
T6920 |
ON123300 |
ON123300 is a potent and multi-targeted kinase inhibitor for CDK4/Ark5/PDGFRβ/FGFR1/RET/Fyn (IC50: 3.9/5/26/26/9.2/11nM). |
T6940 |
PHA767491 HCl |
PHA-767491 is an effective ATP-competitive dual Cdc7/CDK9 inhibitor (IC50: 10/34 nM). It has ~20-fold selectivity against GSK3-β and CDK1/2, 50-fold selectivit...
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T7093 |
Rafoxanide |
Rafoxanide as a dual CDK4/6 inhibitor for the treatment of skin cancer. Rafoxanide is a salicylanilide used as an anthelmintic. It is used to treat fluke, hookw...
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T7167 |
Purvalanol B |
Purvalanol B is a CDK inhibitor that inhibits Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B (IC50s = 6, 9, 6, and 6 nM, respectively) |
T7296 |
THZ2 |
THZ2, an analog of THZ1, is a potent and selective CDK7 inhibitor(IC50:13.9 nM),with the potential to treat Triple-negative breast cancer (TNBC). |
T7426 |
Alsterpaullone |
Alsterpaullone is a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells Through Apoptosis-Inducing Effec |
T7698 |
BS194 |
BS194 is as a potent cyclin-dependent protein kinases (CDKs) inhibitor. |
T7810 |
LY-3177833 |
LY-3177833 is an Cdc7 kinase inhibitor (IC50 : 3.3 nM) |
T8230 |
PNU 112455A |
PNU 112455A is an ATP site competetive inhibitor of CDK2 and CDK5,binds to the ATP site of CDK2 and CDK5 with Kms of 3.6 and 3.2 μM, respectively. |
T8325 |
SR-4835 |
SR-4835 is a highly selective dual inhibitor of CDK12 and CDK13(CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM), which disables triple-negative breast cancer (TN...
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T8378 |
AS2863619 |
AS2863619 is an orally active inhibitor of cyclin-dependent kinase 8 (CDK8) and CDK19 (IC50s of 0.61 nM and 4.28 nM, respectively). |
T8430 |
Senexin B |
Senexin B is a potent and selective inhibitor of CDK8/19(CDK8 and CDK19 with Kds of 140 nM and 80 nM). |
T8463 |
PF-06873600 |
PF-06873600 is a selective and orally bioavailable cyclin-dependent kinase (CDK) inhibitor(CDK2, CDK4 and CDK6 with Ki of 0.09 nM, 0.13 nM and 0.16 nM, respecti...
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T8484 |
JSH-150 |
JSH-150 is a highly selective CDK9 inhibitor(IC50 : 1 nM). |
TL0017 |
Aristolactam AIIIa |
Aristolactam AIIIa is a new type of Plk1 inhibitors, targeting the Polo Box domain (PBD), it has anti-tumor activity. Aristolactam IIIa shows inhibition of plat...
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TMA1743 |
Ergosterol peroxide |
Ergosterol peroxide is an inhibitor of osteoclast differentiation, which has antiviral, trypanocidal, antitumor, and antiangiogenic actions, it can stimulate Fo...
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TN1039 |
Tamarixetin |
Tamarixetin has vasodilator effects in rat isolated vessels. Tamarixetin has cytotoxic against leukemia cells and in particular P-glycoprotein- overexpressing K...
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TN1222 |
23-epi-26-Deoxyactein |
23-epi-26-Deoxyactein has anti-inflammatory activity, it inhibits nitric oxide production by reducing iNOS expression without affecting activity of the enzyme. ...
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TN1651 |
Furanodiene |
Furanodiene has anti-inflammatory and antioxidant activities, it is active against gram-positive bacteria and Candida albicans. |
TN1663 |
Ganoderic acid DM |
Ganoderic acid DM is an antiandrogenic osteoclastogenesis inhibitor, it especially suppresses the expression of c-Fos and nuclear factor of activated T cells c1...
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TN1664 |
Ganoderic acid H |
Ganoderic acid H is a potent antitumour agent, it mediates its biological effects through the inhibition of transcription factors AP-1 and NF-kappaB, resulting ...
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TN1728 |
Hellebrigenin |
Hellebrigenin has anti-hepatoma activities, it induces cell cycle arrest and apoptosis in human hepatocellular carcinoma HepG2 cells through inhibition of Akt. ...
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TN2080 |
Pinoresinol |
Pinoresinol has antiinflammatory, hepatoprotective, and fungicidal activities, it can protect pial microcirculation from I-reperfusion injury, to increase nitri...
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TN3247 |
7-O-Prenylscopoletin |
7-O-Prenylscopoletin and cedrelopsin show high antiproliferative activities against cancer cell lines. |
TN3673 |
Clausine Z |
Clausine Z exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro. |
TN3719 |
Cristacarpin |
Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-...
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TN3802 |
Dehydrodiconiferyl alcohol |
Dehydrodiconiferyl alcohol shows anti-adipogenic and anti-lipogenic effects in 3T3-L1 cells and primary mouse embryonic fibroblasts. Dehydrodiconiferyl alcohol ...
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TN4263 |
Isoangustone A |
Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation...
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TN4394 |
Kobophenol A |
Kobophenol A has antimicrobial, and anti-inflammatory activities, it might be a candidate for treatment of inflammatory bone diseases relevant to osteoblast cel...
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TN4411 |
Lappaol F |
1. Lappaol F has antioxidant and antiaging properties, it may promote the C. elegans longevity and stress resistance through a JNK-1-DAF-16 cascade. <br/> 2. La...
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TQ0053 |
CYC065 |
CYC065 is an orally available, second-generation ATP-competitive inhibitor of CDK2/CDK9 kinases (IC50s: 5/26 nM). |
TQ0060 |
LY2857785 |
LY2857785 is a type I competitive and reversible ATP kinase inhibitor against CDK7/CDK8/CDK9 (IC50s: 246 nM/16 nM/11 nM). |
TQ0068 |
NVP-LCQ195 |
NVP-LCQ195 (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM). |
TQ0078 |
CDK inhibitor II |
CDK-IN-2 is a potent and specific CDK9 inhibitor (IC50: <8 nM). |
TQ0266 |
MSC2530818 |
MSC2530818 is an effective, selective and orally available CDK8 inhibitor (IC50: 2.6 nM). |