CDK

Cyclin-dependent kinases (CDKs) are the families of protein kinases first discovered for their role in regulating the cell cycle. They are also involved in regulating transcription, mRNA processing, and the differentiation of nerve cells.They are present in all known eukaryotes, and their regulatory function in the cell cycle has been evolutionarily conserved.

Cat. No.	Product name	CAS No.	Purity
T17305	CDK8-IN-4	1613638-82-6	98%
T17305	CDK8-IN-4 is an inhibitor of CDK8 (IC50: 0.2 nM).
T10735	CDK4/6/1 Inhibitor	2099128-41-1	98%
T10735	CDK4/6/1 Inhibitor is a type of CDK4/6 inhibitor (IC50s: 3 and 1 nM). CDK4/6 inhibitor is a class of compounds used for the treatment of some types of hormone re...
T14136	AG-024322	837364-57-5	98%
T14136	AG-024322 is a potent ATP-competitive inhibitor of pan-CDK against cell cycle kinases CDK1, CDK2, and CDK4(Ki values in the 1-3 nM range)
TN3719	Cristacarpin	74515-47-2	98%
TN3719	Cristacarpin exhibits moderate but selective activity towards DNA repair-deficient yeast mutants. It promotes endoplasmic reticulum (ER) stress, leading to sub-l...
T10743	CDK9-IN-11	T10743	98%
T10743	CDK9-IN-11 is a potent CDK9 inhibitor. CDK9-IN-11 is the ligand for the PROTAC CDK9 Degrader-1 [1].
T15730	Ribociclib hydrochloride	1211443-80-9	98%
T15730	Ribociclib hydrochloride is a highly specific CDK4/6 inhibitor (IC50: 10 nM and 39 nM, respectively). It is over 1,000-fold less potent against the cyclin B/CDK1...
T10741	CDK9-IN-1	1415559-43-1	98%
T10741	CDK9-IN-1 is a novel, selective CDK9 inhibitor for the treatment of HIV infection (IC50: 39 nM for CDK9/CycT1).
TN3673	Clausine Z	866111-14-0	98%
TN3673	Clausine Z exhibits inhibitory activity against cyclin-dependent kinase 5 (CDK5) and shows protective effects on cerebellar granule neurons in vitro.
TN4263	Isoangustone A	129280-34-8	98%
TN4263	Isoangustone A has antitumor activity, it can induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells, it inhibits cell proliferation ...
T2653	SB1317	1204918-72-8	98%
T2653	SB1317 is a potent inhibitor of cyclin dependant kinases (CDKs), Janus kinase 2 (JAK2), and Fms-like tyrosine kinase-3 (FLT3).
T13202L	Trilaciclib	1374743-00-6	98%
T13202L	Trilaciclib is an inhibitor of CDK4/6 (IC50s: 1 nM and 4 nM for CDK4 and CDK6, respectively).
T10739	CDK8/19-IN-1	1818427-07-4	98%
T10739	CDK8/19-IN-1 is a selective and oral bioavailable CDK8/19 dual inhibitor (IC50s: 0.46 nM, 0.99 nM, and 270 nM for CDK8, CDK19, and CDK9).
T13425	(1S,3R,5R)-PIM447 dihydrochloride	T13425	98%
T13425	(1S,3R,5R)-PIM447 (dihydrochloride) an inhibitor of PIM(IC50 of 0.095 μM for Pim1, 0.522 μM for Pim2 and 0.369 μM for Pim3).
T13627	CP-10	2366268-80-4	98%
T13627	CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells inclu...
T25125	AZA197	1249398-09-1	98%
T25125	AZA197 is a selective Cdc42 inhibitor. It acts by inhibiting primary colon cancer growth and prolonging survival in a preclinical mouse xenograft model by downre...
T13309	Voruciclib hydrochloride	1000023-05-1	98%
T13309	Voruciclib hydrochloride is an orally active and selective inhibitor of CDK (Ki: 0.626 nM-9.1 nM).
T12617	(R)-CR8 trihydrochloride	1786438-30-9	98%
T12617	(R)-CR8 trihydrochloride is a potent inhibitor CDK1/2/5/7/9.
T11656	Indoramin D5	57165-41-0	98%
T11656	Indoramin D5 is a piperidine antiadrenergic agent. Indoramin D5 is deuterium labeled Indoramin.
T64373	CDK1-IN-2		98%
T64373	CDK1-IN-2 is a CDK1 inhibitor with IC50 of 5.8 μM. A broad-spectrum kinase profiling of CDK1-IN-2 revealed nonselective inhibition of several kinases.
T12642L	Simurosertib	1330782-76-7	98%
T12642L	Simurosertib is a selective and ATP-competitive cell division cycle 7 kinase inhibitor (IC50: <0.3 nM).