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TL12-186

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Purity:98.2%

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COA HPLC HNMR

TL12-186

Catalog No. T34888Cas No. 2250025-88-6

TL12-186 is a Cereblon-dependent kinase degrader that degrades CDK, BTK, FLT3, Aurora and other kinases.TL12-186 inhibits CDK2/cyclin A and CDK9/cyclin T1 with IC50s of 73 and 55 nM, respectively.

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Pack Size	Price	Availability
1 mg	$116	In Stock
5 mg	$288	In Stock
10 mg	$482	In Stock
25 mg	$892	In Stock
50 mg	$1,220	In Stock
100 mg	$1,650	In Stock
1 mL x 10 mM (in DMSO)	$490	In Stock

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Product Introduction

Bioactivity

Description	TL12-186 is a Cereblon-dependent kinase degrader that degrades CDK, BTK, FLT3, Aurora and other kinases.TL12-186 inhibits CDK2/cyclin A and CDK9/cyclin T1 with IC50s of 73 and 55 nM, respectively.
In vitro	TL12-186 demonstrates over 90% inhibition against 193 kinases at a screening concentration of 1 μM[1]. Utilizing AlphaScreen binding assays, it exhibits potent binding to CRBN with an IC50 of 12 nM[1]. Displaying CRBN-dependent pharmacological effects, TL12-186 (1-10000 nM; 2 days) exerts 13 to 15 times stronger inhibition of cell survival in WT cells compared to CRBN-/- cells[1]. Moreover, at concentrations ranging from 10 to 10000 nM for 4 hours, TL12-186 selectively inhibits STAT1 phosphorylation without inducing degradation of JAK1/2[1].
Alias	TL12 186, TL12186

Chemical Properties

Molecular Weight	931.46
Formula	C44H51ClN10O9S
Cas No.	2250025-88-6

Storage & Solubility Information

Storage

keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 200 mg/mL (214.72 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0736 mL	5.3679 mL	10.7358 mL	53.6792 mL
5 mM	0.2147 mL	1.0736 mL	2.1472 mL	10.7358 mL
10 mM	0.1074 mL	0.5368 mL	1.0736 mL	5.3679 mL
20 mM	0.0537 mL	0.2684 mL	0.5368 mL	2.6840 mL
50 mM	0.0215 mL	0.1074 mL	0.2147 mL	1.0736 mL
100 mM	0.0107 mL	0.0537 mL	0.1074 mL	0.5368 mL

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