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Voruciclib

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Purity:99.89%

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COA HPLC HNMR

Voruciclib

Catalog No. T10096LCas No. 1000023-04-0

Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the transcriptional regulator of MCL-1.

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Pack Size	Price	Availability
1 mg	$147	In Stock
5 mg	$289	In Stock
10 mg	$455	In Stock
25 mg	$889	In Stock
1 mL x 10 mM (in DMSO)	$298	In Stock

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Product Introduction

Bioactivity

Description	Voruciclib is an orally active and selective CDK inhibitor (Ki: 0.626 nM-9.1 nM). Voruciclib represses the expression of MCL-1 in multiple models of diffuse large B-cell lymphoma. Voruciclib effectively blocks CDK9, the transcriptional regulator of MCL-1.
In vitro	Voruciclib hydrochloride has Ki values for CDK inhibitor such as CDK9/cyc T2 of 0.626 nM, CDK9/cyc T1 of 1.68 nM, CDK6/cyc D1 of 2.92 nM, CDK4/cyc D1 of 3.96 nM, CDK1/cyc B of 5.4 nM, and CDK1/cyc A of 9.1 nM[1].Voruciclib (0.5-5 μM; 6 hours) displays targeted downregulation of MCL-1 in both ABC and GCB subtypes[1].
In vivo	In ABC subtypes (U2932, RIVA, OCI-LY10), GCB subtypes (SU-DHL-4, NU-DHL-1) xenografted in Female NOD.CB17-Prkdcscid/NCrHsd mice, Combination of 200 mpk Voruciclib hydrochloride and Venetoclax (10 mpk, 1 mpk, 50 mpk, 25 mpk in U2932, RIVA, SU-DHL-4 and NU-DHL-1, respectively) causes increase tumor growth inhibition compared to either drug alone in U2932, RIVA, SU-DHL-4, and NU-DHL-1 models of DLBCL [1].

Chemical Properties

Molecular Weight	469.84
Formula	C22H19ClF3NO5
Cas No.	1000023-04-0

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 42.5 mg/mL (90.46 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1284 mL	10.6419 mL	21.2838 mL	106.4192 mL
5 mM	0.4257 mL	2.1284 mL	4.2568 mL	21.2838 mL
10 mM	0.2128 mL	1.0642 mL	2.1284 mL	10.6419 mL
20 mM	0.1064 mL	0.5321 mL	1.0642 mL	5.3210 mL
50 mM	0.0426 mL	0.2128 mL	0.4257 mL	2.1284 mL

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