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(2S,3R)-Voruciclib hydrochloride

Name: (2S,3R)-Voruciclib hydrochloride
Brand: TargetMol
SKU: T10096L2
Rating: 4.5 (1 reviews)

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Catalog No. T10096L2Cas No. 1253647-46-9

Alias (2S,3R)-Voruciclib hydrochloride (1253731-24-6 free base)

(2S,3R)-Voruciclib hydrochloride is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.

(2S,3R)-Voruciclib hydrochloride

😃Good

Catalog No. T10096L2Alias (2S,3R)-Voruciclib hydrochloride (1253731-24-6 free base)Cas No. 1253647-46-9

(2S,3R)-Voruciclib hydrochloride is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.

Pack Size	Price	Availability
25 mg	$3,420	3-6 months
50 mg	$4,280	3-6 months
100 mg	$5,600	3-6 months

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Product Introduction

Bioactivity

Description	(2S,3R)-Voruciclib hydrochloride is the (2S,3R)-enantiomer of Voruciclib. It is an orally active CDK inhibitor.
In vitro	(2S,3R)-Voruciclib (Compound B, formula I) is used in combination with a compound capable of inhibiting EGFR kinase activity and Gemcitabine to treat pancreatic cancer.
Alias	(2S,3R)-Voruciclib hydrochloride (1253731-24-6 free base)

Chemical Properties

Molecular Weight	506.3
Formula	C₂₂H₂₀Cl₂F₃NO₅
Cas No.	1253647-46-9

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 250 mg/mL (493.78 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9751 mL	9.8756 mL	19.7511 mL	98.7557 mL
5 mM	0.3950 mL	1.9751 mL	3.9502 mL	19.7511 mL
10 mM	0.1975 mL	0.9876 mL	1.9751 mL	9.8756 mL
20 mM	0.0988 mL	0.4938 mL	0.9876 mL	4.9378 mL
50 mM	0.0395 mL	0.1975 mL	0.3950 mL	1.9751 mL
100 mM	0.0198 mL	0.0988 mL	0.1975 mL	0.9876 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Voruciclib Hydrochloride1253731-24-6 free base1253731-24-6(2S,3R)Voruciclib hydrochloride(2S,3R) Voruciclib hydrochloride

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