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Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $297 | 8-10 weeks | |
25 mg | $987 | 8-10 weeks | |
50 mg | $1,360 | 8-10 weeks | |
100 mg | $1,860 | 8-10 weeks |
Description | Voruciclib hydrochloride is an orally active and selective CDK inhibitor with a Ki range of 0.626 nM to 9.1 nM. |
Targets&IC50 | CDK9-CyclinT2:0.626 nM (ki), CDK1-CyclinA:9.1 nM (ki), CDK1-CyclinB:5.4 nM (ki), CDK4-CyclinD1:3.96 nM (ki), CDK6-CyclinD1:2.92 nM (ki), CDK9-CyclinT1:1.68 nM (ki) |
In vitro | In both ABC and GCB subtypes, Voruciclib hydrochloride (0.5-5 μM; 6 hours) shows targeted downregulation of MCL-1 . Ki values for each target such as CDK9/cyc T2, CDK9/cyc T1, CDK6/cyc D1, CDK4/cyc D1, CDK1/cyc B, and CDK1/cyc A for Voruciclib hydrochloride are 0.626 nM, 1.68 nM, 2.92 nM, 3.96 nM, 5.4 nM, 9.1 nM, respectively. |
In vivo | Combination of Venetoclax (10 mpk, 1 mpk, 50 mpk, 25 mpk in U2932, RIVA, SU-DHL-4 and NU-DHL-1, respectively) and Voruciclib hydrochloride (200 mpk; Oral gavage) leads to enhance tumor growth inhibition compared to either drug alone in U2932, RIVA, SU-DHL-4 (six days per week for 4 weeks), and NU-DHL-1 models (five days per week for 3 weeks) of DLBCL. |
Molecular Weight | 506.3 |
Formula | C22H20Cl2F3NO5 |
Cas No. | 1000023-05-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 250 mg/mL (493.78 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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