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Voruciclib hydrochloride

Name: Voruciclib hydrochloride
Brand: TargetMol
SKU: T13309
Rating: 4.5 (1 reviews)

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Catalog No. T13309Cas No. 1000023-05-1

Voruciclib hydrochloride is an orally active and selective CDK inhibitor with a Ki range of 0.626 nM to 9.1 nM.

Voruciclib hydrochloride

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Catalog No. T13309Cas No. 1000023-05-1

Voruciclib hydrochloride is an orally active and selective CDK inhibitor with a Ki range of 0.626 nM to 9.1 nM.

Pack Size	Price	Availability
5 mg	$1,258	8-10 weeks
25 mg	Inquiry	8-10 weeks
50 mg	Inquiry	8-10 weeks
100 mg	Inquiry	8-10 weeks

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Product Introduction

Bioactivity

Description	Voruciclib hydrochloride is an orally active and selective CDK inhibitor with a Ki range of 0.626 nM to 9.1 nM.
Targets&IC50	CDK1-CyclinA:9.1 nM (ki), CDK1-CyclinB:5.4 nM (ki), CDK9-CyclinT1:1.68 nM (ki), CDK4-CyclinD1:3.96 nM (ki), CDK6-CyclinD1:2.92 nM (ki), CDK9-CyclinT2:0.626 nM (ki)
In vitro	In both ABC and GCB subtypes, Voruciclib hydrochloride (0.5-5 μM; 6 hours) shows targeted downregulation of MCL-1 . Ki values for each target such as CDK9/cyc T2, CDK9/cyc T1, CDK6/cyc D1, CDK4/cyc D1, CDK1/cyc B, and CDK1/cyc A for Voruciclib hydrochloride are 0.626 nM, 1.68 nM, 2.92 nM, 3.96 nM, 5.4 nM, 9.1 nM, respectively.
In vivo	Combination of Venetoclax (10 mpk, 1 mpk, 50 mpk, 25 mpk in U2932, RIVA, SU-DHL-4 and NU-DHL-1, respectively) and Voruciclib hydrochloride (200 mpk; Oral gavage) leads to enhance tumor growth inhibition compared to either drug alone in U2932, RIVA, SU-DHL-4 (six days per week for 4 weeks), and NU-DHL-1 models (five days per week for 3 weeks) of DLBCL.

Chemical Properties

Molecular Weight	506.3
Formula	C₂₂H₂₀Cl₂F₃NO₅
Cas No.	1000023-05-1
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 250 mg/mL (493.78 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9751 mL	9.8756 mL	19.7511 mL	98.7557 mL
5 mM	0.3950 mL	1.9751 mL	3.9502 mL	19.7511 mL
10 mM	0.1975 mL	0.9876 mL	1.9751 mL	9.8756 mL
20 mM	0.0988 mL	0.4938 mL	0.9876 mL	4.9378 mL
50 mM	0.0395 mL	0.1975 mL	0.3950 mL	1.9751 mL
100 mM	0.0198 mL	0.0988 mL	0.1975 mL	0.9876 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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