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AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd values of 50 nM for CDK2(WT), 18.6 nM for CDK2(C118L), 15.4 nM for CDK2(A144C), and 9.7 nM for CDK2(C118L/A144C).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $43 | In Stock | |
10 mg | $70 | In Stock | |
25 mg | $148 | In Stock | |
50 mg | $223 | In Stock | |
100 mg | $358 | In Stock | |
200 mg | $497 | In Stock | |
1 mL x 10 mM (in DMSO) | $59 | In Stock |
Description | AUZ 454 (K03861) is a type II CDK2 inhibitor with Kd values of 50 nM for CDK2(WT), 18.6 nM for CDK2(C118L), 15.4 nM for CDK2(A144C), and 9.7 nM for CDK2(C118L/A144C). |
Targets&IC50 | CDK2 (A144C):15.4 nM(Kd), CDK2 (WT):50 nM(Kd), CDK2 (C118L):18.6 nM(Kd), CDK2 (C118L/A144C):9.7 nM(Kd) |
In vitro | K03861 inhibits CDK2 activity by competing with binding of activating cyclins. [1] |
Alias | K03861 |
Molecular Weight | 501.5 |
Formula | C24H26F3N7O2 |
Cas No. | 853299-07-7 |
Smiles | CN1CCN(Cc2ccc(NC(=O)Nc3ccc(Oc4ccnc(N)n4)cc3)cc2C(F)(F)F)CC1 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 12 mg/mL (23.9 mM) DMSO: 93 mg/mL (185.4 mM) H2O: < 1 mg/mL (insoluble or slightly soluble) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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