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CDKI-73

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Purity:98.11%

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COA HNMR LCMS

CDKI-73

Catalog No. T14919Cas No. 1421693-22-2

CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin.

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Pack Size	Price	Availability
1 mg	$146	In Stock
2 mg	$198	In Stock
5 mg	$308	In Stock
10 mg	$443	In Stock
25 mg	$732	In Stock
50 mg	$987	In Stock
100 mg	$1,390	In Stock
1 mL x 10 mM (in DMSO)	$323	In Stock

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Product Introduction

Bioactivity

Description	CDKI-73 is a potent CDK9 inhibitor (Ki: 4 nM). It shows selective toxicity to CLL cells(LD50=80 nM) versus normal B cell and normal CD34+ cell(LD50>20 uM).The inhibition of CDK9 induces apoptosis and potentiates the effect of cisplatin.
In vitro	CDKI-73, one of the most potent CDK9 inhibitors, against a panel of AML cell lines and samples derived from 97 patients.?CDKI-73 induced cancer cells undergoing apoptosis through transcriptional downregulation of anti-apoptotic proteins Bcl-2, Mcl-1 and XIAP by majorly targeting CDK9[3].
In vivo	CDKI-73 exhibited a favorable pharmacokinetic profile with oral bioavailability of F = 56% following a single intravenous bolus dose at 2 mg/kg and an oral dose at 10 mg/kg in mice [1].

Chemical Properties

Molecular Weight	394.45
Formula	C15H15FN6O2S2
Cas No.	1421693-22-2

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 52 mg/mL (131.83 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5352 mL	12.6759 mL	25.3518 mL	126.7588 mL
5 mM	0.5070 mL	2.5352 mL	5.0704 mL	25.3518 mL
10 mM	0.2535 mL	1.2676 mL	2.5352 mL	12.6759 mL
20 mM	0.1268 mL	0.6338 mL	1.2676 mL	6.3379 mL
50 mM	0.0507 mL	0.2535 mL	0.5070 mL	2.5352 mL
100 mM	0.0254 mL	0.1268 mL	0.2535 mL	1.2676 mL

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