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NU6140
Catalog No. T16359Cas No. 444723-13-1
NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and has anti-cancer activity.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $41 | In Stock | |
| 2 mg | $58 | In Stock | |
| 5 mg | $97 | In Stock | |
| 10 mg | $163 | In Stock | |
| 25 mg | $328 | In Stock | |
| 50 mg | $528 | In Stock | |
| 100 mg | $769 | In Stock | |
| 500 mg | $1,580 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $108 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and has anti-cancer activity. |
| In vitro | NU6140 enhances catalytic activity of capase-9 and capase-3, causes an increase in the sub-G1 apoptotic cell population. NU6140 is less active on CDK1-cyclin B, CDK4-cyclin D, CDK5-p25 and CDK7-cyclin H (IC50s: 6.6, 5.5, 15 and 3.9 μM, respectively)[1]. |
| Molecular Weight | 422.52 |
| Formula | C23H30N6O2 |
| Cas No. | 444723-13-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (591.69 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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