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CDK8-IN-12

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Purity:99.83%

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COA HPLC HNMR

CDK8-IN-12

Catalog No. T72048Cas No. 2613307-67-6

CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showed anti-proliferative activity against MV4-11 cells.

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Pack Size	Price	Availability
1 mg	$79	In Stock
5 mg	$188	In Stock
10 mg	$279	In Stock
25 mg	$479	In Stock
50 mg	$686	In Stock
100 mg	$997	In Stock
1 mL x 10 mM (in DMSO)	$197	In Stock

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Product Introduction

Bioactivity

Description	CDK8-IN-12 is a selective, potent and orally active inhibitor of CDK8 (Ki: 14 nM) and is an anti-cancer agent. CDK8-IN-12 inhibits GSK-3α, GSK-3β and PCK-θ with Ki of 13 nM, 4 nM and 109 nM respectively. CDK8-IN-12 showed anti-proliferative activity against MV4-11 cells.
Targets&IC50	CDK8:14 nM(Ki), MV-4-11 cells:0.36 μM(GI50), GSK-3α:13 nM(ki), GSK-3β:4 nM(ki), PCKθ:109 nM(ki)
In vitro	CDK8-IN-12 (0.36, 0.72 μM ; 2 h) significantly reduced the phosphorylation of STAT1 serine 727.[1]
In vivo	CDK8-IN-12 (intravenous administration ; 5 mg/kg in rats ; 2 mg/kg in mice) had a T1/2 of 0.9 h and 0.34 h in rats and mice, respectively.[1]

Chemical Properties

Molecular Weight	381.86
Formula	C21H20ClN3O2
Cas No.	2613307-67-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 27.5 mg/mL (72.02 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6188 mL	13.0938 mL	26.1876 mL	130.9380 mL
5 mM	0.5238 mL	2.6188 mL	5.2375 mL	26.1876 mL
10 mM	0.2619 mL	1.3094 mL	2.6188 mL	13.0938 mL
20 mM	0.1309 mL	0.6547 mL	1.3094 mL	6.5469 mL
50 mM	0.0524 mL	0.2619 mL	0.5238 mL	2.6188 mL

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