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AS-0141
🥰Excellent
Catalog No. T10728Cas No. 1402057-88-8
Alias SRA-141, PNT-141, Cdc7-IN-6
AS-0141 (Cdc7-IN-6) is a potent Cdc7 kinase inhibitor (IC50=4 nM) with anti-tumor activity.
AS-0141
🥰Excellent
Purity: 100%
Catalog No. T10728Alias SRA-141, PNT-141, Cdc7-IN-6Cas No. 1402057-88-8
AS-0141 (Cdc7-IN-6) is a potent Cdc7 kinase inhibitor (IC50=4 nM) with anti-tumor activity.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $58 | In Stock | |
| 5 mg | $148 | In Stock | |
| 10 mg | $222 | In Stock | |
| 25 mg | $373 | In Stock |
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Purity:100%
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.Product Introduction
Bioactivity
Chemical Properties
| Description | AS-0141 (Cdc7-IN-6) is a potent Cdc7 kinase inhibitor (IC50=4 nM) with anti-tumor activity. |
| In vitro | AS-0141 demonstrates potent inhibitory activity (IC50<3 µΜ) across a variety of solid tumor cell lines, including sarcoma (143B, CADO-ES1, RD-ES, A673), bladder (5673, RT1 12/84), colon and cecum (Colo-205, DLD-1, LS1034, SK-CO-1, SNU-C1), renal (U0.31), melanoma (A2058, A875), head-and-neck (CNE-2Z, RPMI-2650), and gastric (HGC-27) lineages[1]. |
| Alias | SRA-141, PNT-141, Cdc7-IN-6 |
| Molecular Weight | 465.43 |
| Formula | C21H22F3N5O4 |
| Cas No. | 1402057-88-8 |
| Smiles | N(C1=C(C(OCC)=O)C(=O)C(=CC=2C=3C(NC2)=NC=CC3)O1)N4CCN(CC(F)(F)F)CC4 |
| Relative Density. | 1.47 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 76.5 mg/mL (164.4 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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