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AS-0141

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Purity:100%

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COA HNMR HPLC

AS-0141

Catalog No. T10728Cas No. 1402057-88-8

AS-0141 (Cdc7-IN-6) is a potent Cdc7 kinase inhibitor (IC50=4 nM) with anti-tumor activity.

With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.

Pack Size	Price	Availability
1 mg	$97	In Stock
5 mg	$249	In Stock
10 mg	$370	In Stock

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Product Introduction

Bioactivity

Description	AS-0141 (Cdc7-IN-6) is a potent Cdc7 kinase inhibitor (IC50=4 nM) with anti-tumor activity.
In vitro	AS-0141 demonstrates potent inhibitory activity (IC50<3 µΜ) across a variety of solid tumor cell lines, including sarcoma (143B, CADO-ES1, RD-ES, A673), bladder (5673, RT1 12/84), colon and cecum (Colo-205, DLD-1, LS1034, SK-CO-1, SNU-C1), renal (U0.31), melanoma (A2058, A875), head-and-neck (CNE-2Z, RPMI-2650), and gastric (HGC-27) lineages[1].
Alias	Cdc7-IN-6, PNT-141, SRA-141

Chemical Properties

Molecular Weight	465.43
Formula	C21H22F3N5O4
Cas No.	1402057-88-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 76.5 mg/mL (164.4 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1486 mL	10.7428 mL	21.4855 mL	107.4275 mL
5 mM	0.4297 mL	2.1486 mL	4.2971 mL	21.4855 mL
10 mM	0.2149 mL	1.0743 mL	2.1486 mL	10.7428 mL
20 mM	0.1074 mL	0.5371 mL	1.0743 mL	5.3714 mL
50 mM	0.0430 mL	0.2149 mL	0.4297 mL	2.1486 mL
100 mM	0.0215 mL	0.1074 mL	0.2149 mL	1.0743 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc