Shopping Cart
- Remove All
- Your shopping cart is currently empty
Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $39 | In Stock | |
5 mg | $89 | In Stock | |
10 mg | $129 | In Stock | |
25 mg | $263 | In Stock | |
50 mg | $396 | In Stock | |
100 mg | $591 | In Stock | |
200 mg | $857 | In Stock | |
1 mL x 10 mM (in DMSO) | $98 | In Stock |
Description | Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease. |
Targets&IC50 | JNK3:1 μM (IC50), JNK1:0.8 μM (IC50), JNK2:1.4 μM (IC50) |
In vitro | clear efficacy of I3M + Tq combinations in LC models mediated by suppressing Akt/mTOR/NFκB signalling. |
In vivo | indirubin-3'-monoxime improved the morphology and increased the survival rate of SH-SY5Y cells exposed to amyloid-beta 25-35 (Aβ25-35), and also suppressed apoptosis by reducing tau phosphorylation at Ser199 and Thr205.?Furthermore, indirubin-3'-monoxime inhibited phosphorylation of glycogen synthase kinase-3β (GSK-3β).?indirubin-3'-monoxime reduced Aβ25-35-induced apoptosis by suppressing tau hyperphosphorylation via a GSK-3β-mediated mechanism.?Indirubin-3'-monoxime is a promising drug candidate for Alzheimer's disease. |
Alias | Indirubin-3'-monoxime |
Molecular Weight | 277.28 |
Formula | C16H11N3O2 |
Cas No. | 667463-82-3 |
Smiles | O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccccc12 |
Relative Density. | 1.50 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 55 mg/ml (198.36 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.