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Indirubin-3′-oxime

🥰Excellent
Catalog No. T9138Cas No. 667463-82-3
Alias Indirubin-3'-monoxime

Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.

Indirubin-3′-oxime

Indirubin-3′-oxime

🥰Excellent
Purity: 98.34%
Catalog No. T9138Alias Indirubin-3'-monoximeCas No. 667463-82-3
Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
Pack SizePriceAvailabilityQuantity
1 mg$39In Stock
5 mg$89In Stock
10 mg$129In Stock
25 mg$263In Stock
50 mg$396In Stock
100 mg$591In Stock
200 mg$857In Stock
1 mL x 10 mM (in DMSO)$98In Stock
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Purity:98.34%
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Product Introduction

Bioactivity
Description
Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
Targets&IC50
JNK3:1 μM (IC50), JNK1:0.8 μM (IC50), JNK2:1.4 μM (IC50)
In vitro
clear efficacy of I3M + Tq combinations in LC models mediated by suppressing Akt/mTOR/NFκB signalling.
In vivo
indirubin-3'-monoxime improved the morphology and increased the survival rate of SH-SY5Y cells exposed to amyloid-beta 25-35 (Aβ25-35), and also suppressed apoptosis by reducing tau phosphorylation at Ser199 and Thr205.?Furthermore, indirubin-3'-monoxime inhibited phosphorylation of glycogen synthase kinase-3β (GSK-3β).?indirubin-3'-monoxime reduced Aβ25-35-induced apoptosis by suppressing tau hyperphosphorylation via a GSK-3β-mediated mechanism.?Indirubin-3'-monoxime is a promising drug candidate for Alzheimer's disease.
AliasIndirubin-3'-monoxime
Chemical Properties
Molecular Weight277.28
FormulaC16H11N3O2
Cas No.667463-82-3
SmilesO\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2ccccc12
Relative Density.1.50 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/ml (198.36 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.6065 mL18.0323 mL36.0646 mL180.3231 mL
5 mM0.7213 mL3.6065 mL7.2129 mL36.0646 mL
10 mM0.3606 mL1.8032 mL3.6065 mL18.0323 mL
20 mM0.1803 mL0.9016 mL1.8032 mL9.0162 mL
50 mM0.0721 mL0.3606 mL0.7213 mL3.6065 mL
100 mM0.0361 mL0.1803 mL0.3606 mL1.8032 mL

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