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CDK9-IN-2
🥰Excellent
Catalog No. T14918Cas No. 1263369-28-3
CDK9-IN-2 is a specific CDK9 inhibitor with an IC50 of 5 nM in the A2058 skin cell line (72 hours) and 7 nM in the H929 multiple myeloma cell line (72 hours).
CDK9-IN-2
🥰Excellent
Purity: 99%
Catalog No. T14918Cas No. 1263369-28-3
CDK9-IN-2 is a specific CDK9 inhibitor with an IC50 of 5 nM in the A2058 skin cell line (72 hours) and 7 nM in the H929 multiple myeloma cell line (72 hours).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $80 | In Stock | |
| 5 mg | $197 | In Stock | |
| 10 mg | $296 | In Stock | |
| 25 mg | $512 | In Stock | |
| 50 mg | $743 | In Stock | |
| 100 mg | $1,050 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $217 | In Stock |
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Purity:99%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CDK9-IN-2 is a specific CDK9 inhibitor with an IC50 of 5 nM in the A2058 skin cell line (72 hours) and 7 nM in the H929 multiple myeloma cell line (72 hours). |
| Targets&IC50 | H929 multiple myeloma cell lines:, CDK9:5 nM |
| In vitro | CDK9-IN-2, at a concentration of 200 nM, decreases MEPCE expression, suggesting MEPCE serves as a pharmacodynamic indicator for CDK9 inhibitors. Moreover, MCL1 protein levels are diminished within 2 hours of CDK9-IN-2 treatment, with further reduction observed after 16 hours of exposure to a higher concentration of 500 nM. |
| Molecular Weight | 425.93 |
| Formula | C23H25ClFN5 |
| Cas No. | 1263369-28-3 |
| Smiles | N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCc2cccc(F)c2)n1 |
| Relative Density. | 1.302 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 70 mg/mL (164.35 mM), Sonication is recommended.  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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