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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $80 | In Stock | |
5 mg | $197 | In Stock | |
10 mg | $296 | In Stock | |
25 mg | $512 | In Stock | |
50 mg | $743 | In Stock | |
100 mg | $1,050 | In Stock | |
1 mL x 10 mM (in DMSO) | $217 | In Stock |
Description | CDK9-IN-2 is a special CDK9 inhibitor and has an IC50 of 5 nM and 7 nM in A2058 skin cell line (72 hours) and H929 multiple myeloma cell line (72 hours), respectively. |
In vitro | CDK9-IN-2, at a concentration of 200 nM, decreases MEPCE expression, suggesting MEPCE serves as a pharmacodynamic indicator for CDK9 inhibitors. Moreover, MCL1 protein levels are diminished within 2 hours of CDK9-IN-2 treatment, with further reduction observed after 16 hours of exposure to a higher concentration of 500 nM. |
Molecular Weight | 425.93 |
Formula | C23H25ClFN5 |
Cas No. | 1263369-28-3 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 70 mg/mL (164.35 mM) ![]() | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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