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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $116 | In Stock | |
2 mg | $169 | In Stock | |
5 mg | $289 | In Stock | |
10 mg | $497 | In Stock | |
25 mg | $793 | In Stock | |
50 mg | $1,130 | In Stock | |
100 mg | $1,520 | In Stock | |
1 mL x 10 mM (in DMSO) | $318 | In Stock |
Description | CDK12-IN-2 (CDK12 inhibitor 2) is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CDK12. |
Targets&IC50 | CDK7:>10 μM (IC50), CDK9:16 μM (IC50), CDK2:>100 μM (IC50), CDK12:52 nM (IC50) |
In vitro | In SK-BR-3 cells, CDK12-IN-2 inhibits the phosphorylation of the CTD Ser2 with an IC50 of 185 nM. CDK12-IN-2 exhibits a growth inhibition with an IC50 of 0.8 μM. CDK12-IN-2 inhibits CDK12 in a time dependent manner with IC50s of 0.0078 μM, 0.042 μM, 0.057 μM,and 0.059 μM, for 0h, 1h, 2h and 5h[1]. |
Alias | CDK12 inhibitor 2, CDK12-IN-2 |
Molecular Weight | 532.64 |
Formula | C32H32N6O2 |
Cas No. | 2244987-03-7 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (75.1 mM), Sonication and heating to 60℃ are recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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