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CDK12-IN-2

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Purity:99.54%

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COA HNMR HPLC

CDK12-IN-2

Catalog No. T39752Cas No. 2244987-03-7

CDK12-IN-2 (CDK12 inhibitor 2) is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CDK12.

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Pack Size	Price	Availability
1 mg	$116	In Stock
2 mg	$169	In Stock
5 mg	$289	In Stock
10 mg	$497	In Stock
25 mg	$793	In Stock
50 mg	$1,130	In Stock
100 mg	$1,520	In Stock
1 mL x 10 mM (in DMSO)	$318	In Stock

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Product Introduction

Bioactivity

Description	CDK12-IN-2 (CDK12 inhibitor 2) is an effective and selective inhibitor of CDK12 with an IC50 of 52 nM, >100 μM, >10 μM and 16 μM for CDK12, CDK2, CDK7, and CDK9. CDK12-IN-2 can be used in studies about the function of CDK12.
Targets&IC50	CDK7:>10 μM (IC50), CDK9:16 μM (IC50), CDK2:>100 μM (IC50), CDK12:52 nM (IC50)
In vitro	In SK-BR-3 cells, CDK12-IN-2 inhibits the phosphorylation of the CTD Ser2 with an IC50 of 185 nM. CDK12-IN-2 exhibits a growth inhibition with an IC50 of 0.8 μM. CDK12-IN-2 inhibits CDK12 in a time dependent manner with IC50s of 0.0078 μM, 0.042 μM, 0.057 μM,and 0.059 μM, for 0h, 1h, 2h and 5h[1].
Alias	CDK12 inhibitor 2, CDK12-IN-2

Chemical Properties

Molecular Weight	532.64
Formula	C32H32N6O2
Cas No.	2244987-03-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 50 mg/mL (75.1 mM), Sonication and heating to 60℃ are recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.8774 mL	9.3872 mL	18.7744 mL	93.8720 mL
5 mM	0.3755 mL	1.8774 mL	3.7549 mL	18.7744 mL
10 mM	0.1877 mL	0.9387 mL	1.8774 mL	9.3872 mL
20 mM	0.0939 mL	0.4694 mL	0.9387 mL	4.6936 mL
50 mM	0.0375 mL	0.1877 mL	0.3755 mL	1.8774 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

CDK12-IN-2

CDK12-IN-2

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Dose Conversion

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