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Purvalanol B

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Catalog No. T7167Cas No. 212844-54-7
Alias NG 95

Purvalanol B (NG 95) is a CDK inhibitor that targets Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B, with IC50 values of 6, 9, 6, and 6 nM, respectively.

Purvalanol B

Purvalanol B

🥰Excellent
Purity: 98.95%
Catalog No. T7167Alias NG 95Cas No. 212844-54-7
Purvalanol B (NG 95) is a CDK inhibitor that targets Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B, with IC50 values of 6, 9, 6, and 6 nM, respectively.
Pack SizePriceAvailabilityQuantity
1 mg30 €In Stock
5 mg63 €In Stock
10 mg82 €In Stock
25 mg143 €In Stock
50 mg214 €In Stock
100 mg322 €In Stock
200 mg486 €In Stock
1 mL x 10 mM (in DMSO)70 €In Stock
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Purity:98.95%
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Product Introduction

Bioactivity
Description
Purvalanol B (NG 95) is a CDK inhibitor that targets Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B, with IC50 values of 6, 9, 6, and 6 nM, respectively.
Targets&IC50
CDK5-p35:6 nM , CDK2-CyclinE:9 nM , CDK2-CyclinA:6 nM , CDK2-CyclinB:6 nM
In vivo
Purvalanol B application decreases the ability of late-stage P.falciparum trophozoites to form multinucleated schizonts and up-regulates proteasome subunits and proteins that contribute to redox homeostasis, which may indicate an increase in oxidative stress as a result of inhibitor application[1].
Animal Research
A SYBR Green I parasite growth assay was used to measure the IC50 of Purvalanol B with P. falciparum (strain W2). Purvalanol B or DMSO control were applied to synchronized parasites 36 hours post invasion and parasites were incubated for 12 hours. Giemsa-stained blood smears were used to determine the effect of Purvalanol B on parasite growth, global quantitative proteomic analysis was used to examine differences in protein expression between Purvalanol B-treated and control parasites and results were confirmed by qPCR[1].
AliasNG 95
Chemical Properties
Molecular Weight432.9
FormulaC20H25ClN6O3
Cas No.212844-54-7
SmilesCC(C)[C@H](CO)Nc1nc(Nc2ccc(C(O)=O)c(Cl)c2)c2ncn(C(C)C)c2n1
Relative Density.1.43 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 40 mg/mL (92.40 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.3100 mL11.5500 mL23.1000 mL115.5001 mL
5 mM0.4620 mL2.3100 mL4.6200 mL23.1000 mL
10 mM0.2310 mL1.1550 mL2.3100 mL11.5500 mL
20 mM0.1155 mL0.5775 mL1.1550 mL5.7750 mL
50 mM0.0462 mL0.2310 mL0.4620 mL2.3100 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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