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Purvalanol B (NG 95) is a CDK inhibitor that targets Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B, with IC50 values of 6, 9, 6, and 6 nM, respectively.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 30 € | In Stock | |
5 mg | 63 € | In Stock | |
10 mg | 82 € | In Stock | |
25 mg | 143 € | In Stock | |
50 mg | 214 € | In Stock | |
100 mg | 322 € | In Stock | |
200 mg | 486 € | In Stock | |
1 mL x 10 mM (in DMSO) | 70 € | In Stock |
Description | Purvalanol B (NG 95) is a CDK inhibitor that targets Cdk2/cyclin A, Cdk2/cyclin E, Cdk5/p35, and Cdk2/cyclin B, with IC50 values of 6, 9, 6, and 6 nM, respectively. |
Targets&IC50 | CDK5-p35:6 nM , CDK2-CyclinE:9 nM , CDK2-CyclinA:6 nM , CDK2-CyclinB:6 nM |
In vivo | Purvalanol B application decreases the ability of late-stage P.falciparum trophozoites to form multinucleated schizonts and up-regulates proteasome subunits and proteins that contribute to redox homeostasis, which may indicate an increase in oxidative stress as a result of inhibitor application[1]. |
Animal Research | A SYBR Green I parasite growth assay was used to measure the IC50 of Purvalanol B with P. falciparum (strain W2). Purvalanol B or DMSO control were applied to synchronized parasites 36 hours post invasion and parasites were incubated for 12 hours. Giemsa-stained blood smears were used to determine the effect of Purvalanol B on parasite growth, global quantitative proteomic analysis was used to examine differences in protein expression between Purvalanol B-treated and control parasites and results were confirmed by qPCR[1]. |
Alias | NG 95 |
Molecular Weight | 432.9 |
Formula | C20H25ClN6O3 |
Cas No. | 212844-54-7 |
Smiles | CC(C)[C@H](CO)Nc1nc(Nc2ccc(C(O)=O)c(Cl)c2)c2ncn(C(C)C)c2n1 |
Relative Density. | 1.43 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 40 mg/mL (92.40 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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