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NVP-LCQ195

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Purity:100%

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COA LCMS HNMR

NVP-LCQ195

Catalog No. TQ0068Cas No. 902156-99-4

NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).

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Pack Size	Price	Availability
1 mg	$67	In Stock
5 mg	$163	In Stock
10 mg	$247	In Stock
25 mg	$472	In Stock
50 mg	$693	In Stock
100 mg	$988	In Stock
500 mg	$1,980	In Stock
1 mL x 10 mM (in DMSO)	$166	In Stock

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Product Introduction

Bioactivity

Description	NVP-LCQ195 (LCQ-195) (AT9311) is a potent inhibitor of CDK1, CDK2, CDK3 and CDK5 (IC50: 1-42 nM).
In vitro	NVP-LCQ195 induced cell cycle arrest and eventual apoptotic cell death of MM cells, even at sub-1 mol/l concentrations, spared non-malignant cells, and overcame the protection conferred to MM cells by stroma or cytokines of the bone marrow milieu. In MM cells, LCQ195 triggered decreased amplitude of transcriptional signatures associated with oncogenesis, drug resistance and stem cell renewal, including signatures of activation of key transcription factors for MM cells e.g. myc, HIF-1a, IRF4[1].
In vivo	Bortezomib-treated MM patients whose tumours had high baseline expression of genes suppressed by LCQ195 had significantly shorter progression-free and overall survival than those with low levels of these transcripts in their MM cells[1].
Alias	AT9311, LCQ-195

Chemical Properties

Molecular Weight	460.33
Formula	C17H19Cl2N5O4S
Cas No.	902156-99-4

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (217.24 mM)

H2O: Insoluble

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1724 mL	10.8618 mL	21.7235 mL	108.6177 mL
5 mM	0.4345 mL	2.1724 mL	4.3447 mL	21.7235 mL
10 mM	0.2172 mL	1.0862 mL	2.1724 mL	10.8618 mL
20 mM	0.1086 mL	0.5431 mL	1.0862 mL	5.4309 mL
50 mM	0.0434 mL	0.2172 mL	0.4345 mL	2.1724 mL
100 mM	0.0217 mL	0.1086 mL	0.2172 mL	1.0862 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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