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Senexin C
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Catalog No. T62702Cas No. 2375554-02-0
Senexin C is a novel orally active and specific CDK8/19 inhibitor with potential anticancer activity.Senexin C is more metabolically stable and potent than Senexin B. Senexin C inhibits the growth of MV4-11 leukaemia cells.
Senexin C
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Purity: 97.91%
Catalog No. T62702Cas No. 2375554-02-0
Senexin C is a novel orally active and specific CDK8/19 inhibitor with potential anticancer activity.Senexin C is more metabolically stable and potent than Senexin B. Senexin C inhibits the growth of MV4-11 leukaemia cells.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 178 € | In Stock | |
| 5 mg | 454 € | In Stock | |
| 10 mg | 777 € | In Stock | |
| 25 mg | 1.605 € | In Stock | |
| 50 mg | 2.745 € | 8-10 weeks | |
| 1 mL x 10 mM (in DMSO) | 501 € | In Stock |
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Purity:97.91%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Senexin C is a novel orally active and specific CDK8/19 inhibitor with potential anticancer activity.Senexin C is more metabolically stable and potent than Senexin B. Senexin C inhibits the growth of MV4-11 leukaemia cells. |
| Targets&IC50 | CDK8-CyclinC:3.6 nM, CDK8-CyclinC:1.4 nM (Kd), CDK8-CyclinC:2.9 nM (Kd) |
| In vitro | Senexin C exhibits high selectivity for CDK8 and CDK19, with similar Kd values of 55 nM and 44 nM respectively for ATP analog binding, while showing much higher Kd values for the other three non-target kinases (HASPIN: 1000 nM; MAP4K2: 940 nM; MYO3B: > 30,000 nM)[1]. |
| In vivo | Tumor-bearing mice（CT26 tumor mode） received Senexin C via intravenous injection at 2.5 mg/kg or orally at 100 mg/kg, and compound concentrations in blood and tumors were measured by LC-MS/MS. The results indicated that Senexin C exhibits favorable tumor PK characteristics and low toxicity[1]. |
| Molecular Weight | 449.55 |
| Formula | C28H27N5O |
| Cas No. | 2375554-02-0 |
| Smiles | N#CC=1C=CC2=NC=CC(NCCC=3C=CC4=CC(=CC=C4C3)C(=O)N5CCN(C)CC5)=C2C1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | DMSO: 20 mg/mL (44.49 mM), Sonication and heating are recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
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